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CXCL16 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844574

Background: CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CXCL16, Active Protein
Full Product Name
CXCL16, Human Recombinant
Product Gene Name
CXCL16 active protein
Product Synonym Names
SRPSOX
Sequence
NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP
Host
E Coli
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Appearance: Lyophilized powder
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
10.1 kDa
OMIM
605398
3D Structure
ModBase 3D Structure for Q9H2A7
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not raise to neutral pH. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Endotoxin Level
< 0.1 ng/mug of protein (<1EU/mug).
Activity (Specifications/test method)
Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-100.0 ng/ml.
Biological Activity
Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-100.0 ng/ml.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CXCL16 active protein

Cytokines; Growth Factors & Hormones; ChemokinesCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Chemokines Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytok
Applications Tested/Suitable for CXCL16 active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of CXCL16 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL16 purchase

MBS844574 is an active protein targeting CXCL16. Also known as CXCL16, Human Recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL16. It may not necessarily be applicable to this product.

NCBI GI #
154816178
NCBI GeneID
58191
NCBI Accession #
NP_001094282.1
UniProt Primary Accession #
Q9H2A7
UniProt Secondary Accession #
Q8TC80; Q96K63; Q9BXD6; Q9H2F6; A0N0N4; A8K7U9; B2RCB0
UniProt Related Accession #
Q9H2A7
GenBank Nucleotide #
NM_001100812.1
NCBI Official Full Name
C-X-C motif chemokine 16
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 16
NCBI Official Symbol
CXCL16
NCBI Official Synonym Symbols
SRPSOX; CXCLG16; SR-PSOX
UniProt Protein Name
C-X-C motif chemokine 16
UniProt Synonym Protein Names
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SR-PSOX; Small-inducible cytokine B16; Transmembrane chemokine CXCL16
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL16
UniProt Synonym Gene Names
SCYB16; SRPSOX; SR-PSOX
UniProt Entry Name
CXL16_HUMAN
NCBI Protein Information
C-X-C motif chemokine 16

UniProt Comments for CXCL16

CXCL16: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: extracellular space; membrane; plasma membrane; extracellular region; integral to membrane

Molecular Function: low-density lipoprotein receptor activity; chemokine activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; response to cytokine stimulus; chemotaxis; positive regulation of cell growth; positive regulation of cell migration
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Research Articles on CXCL16

1. No significant association of the CXCL16 polymorphism was established either with soluble CXCL16 plasma levels or with clinical parameters and course of multiple sclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL16 active protein

 Reference Product  PubMed Publications
 CXCR6 active protein  >155 publications with CXCL16 and CXCR6
 CXCL10 active protein  >49 publications with CXCL16 and CXCL10
 CXCL12 active protein  >34 publications with CXCL16 and CXCL12
 CXCL9 active protein  >28 publications with CXCL16 and CXCL9
 CCL5 active protein  >27 publications with CXCL16 and CCL5
 CXCR3 active protein  >26 publications with CXCL16 and CXCR3
 CXCL13 active protein  >18 publications with CXCL16 and CXCL13
 CCL20 active protein  >18 publications with CXCL16 and CCL20
 CXCL11 active protein  >16 publications with CXCL16 and CXCL11

Pathways associated with CXCL16 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with CXCL16 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >112 publications with CXCL16 and Inflammation
 Cardiovascular Diseases Antibodies  >75 publications with CXCL16 and Cardiovascular Diseases
 Necrosis Antibodies  >64 publications with CXCL16 and Necrosis
 Atherosclerosis Antibodies  >47 publications with CXCL16 and Atherosclerosis
 Disease Models, Animal Antibodies  >38 publications with CXCL16 and Disease Models, Animal
 Kidney Diseases Antibodies  >36 publications with CXCL16 and Kidney Diseases
 Heart Diseases Antibodies  >35 publications with CXCL16 and Heart Diseases
 Carcinoma Antibodies  >30 publications with CXCL16 and Carcinoma
 Nervous System Diseases Antibodies  >24 publications with CXCL16 and Nervous System Diseases
 Fibrosis Antibodies  >21 publications with CXCL16 and Fibrosis

Organs/Tissues associated with CXCL16 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >220 publications with CXCL16 and Blood
 Vascular Antibodies  >80 publications with CXCL16 and Vascular
 Liver Antibodies  >44 publications with CXCL16 and Liver
 Bone Antibodies  >40 publications with CXCL16 and Bone
 Kidney Antibodies  >36 publications with CXCL16 and Kidney
 Lung Antibodies  >33 publications with CXCL16 and Lung
 Heart Antibodies  >27 publications with CXCL16 and Heart
 Bone Marrow Antibodies  >25 publications with CXCL16 and Bone Marrow
 Brain Antibodies  >20 publications with CXCL16 and Brain
 Prostate Antibodies  >16 publications with CXCL16 and Prostate
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