Human PPIB Active Protein – Cat# MBS142454

Cyclophilin-B (PPIB) Human Active Protein

Name: PPIB Active Protein; Cyclophilin-B; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142454
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142454

Description: Cyclophilin-B Human Recombinant produced in E Coli is a single, non-glycosylated,polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. PPIB is purified by proprietary chromatographic… More details

$250 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cyclophilin-B (PPIB), Active Protein

Full Product Name

Recombinant Human Cyclophilin-B

Product Gene Name

PPIB active protein

Product Synonym Names

Cyclophilin B Human; Cyclophilin-B Human Recombinant; Peptidylprolyl isomerase B; PPIase; Rotamase; S-cyclophilin; PPIB; cyclophilin-like protein; peptidyl-prolyl cis-trans isomerase B; Cyclophilin B; SCYLP; CYPB; CYP-S1; MGC2224; MGC14109; Cyclophilin B

Sequence

MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEK GFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAG KDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE

Host

E Coli

Form/Format

1 mg/ml solution containing 20mM Tris-HCl 8.0, 20mM NaCl, 0.5mM DTT and 10% glycerol.
Sterile filtered colorless solution.

Purity/Purification

Greater than 95.0% as determined by SDS-PAGE.

Molecular Weight

23,743 Da

OMIM

123841

3D Structure

ModBase 3D Structure for P23284

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is > 220 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Product Categories/Family for PPIB active protein

Enzymes; Cyclophilin

Other Notes

Small volumes of PPIB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPIB purchase

MBS142454 is an active protein targeting PPIB. Also known as Recombinant Human Cyclophilin-B. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPIB. It may not necessarily be applicable to this product.

NCBI GI #

4758950

NCBI GeneID

5479

NCBI Accession #

NP_000933.1

UniProt Primary Accession #

P23284

UniProt Secondary Accession #

Q6IBH5; Q9BVK5; A8K534

UniProt Related Accession #

P23284

GenBank Nucleotide #

NM_000942.4

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase B

NCBI Official Synonym Full Names

peptidylprolyl isomerase B (cyclophilin B)

NCBI Official Symbol

PPIB

NCBI Official Synonym Symbols

OI9; CYPB; SCYLP; CYP-S1; HEL-S-39

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase B

UniProt Synonym Protein Names

CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP

Protein Family

Probable peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

PPIB

UniProt Synonym Gene Names

CYPB; PPIase B; SCYLP

UniProt Entry Name

PPIB_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase B; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; rotamase B

NCBI Summary for PPIB

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

UniProt Comments for PPIB

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: RNA-binding; Secreted; Secreted, signal peptide; EC 5.2.1.8; Cyclophilin; Chaperone; Isomerase

Chromosomal Location of Human Ortholog: 15q21-q22

Cellular Component: focal adhesion; smooth endoplasmic reticulum; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; endoplasmic reticulum lumen; melanosome; nucleus

Molecular Function: collagen binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; protein complex binding; peptide binding

Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein stabilization; positive regulation of multicellular organism growth

Disease: Osteogenesis Imperfecta, Type Ix

Research Articles on PPIB

1. Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPIB active protein

Reference Product	PubMed Publications
CRTAP active protein	>22 publications with PPIB and CRTAP
LEPRE1 active protein	>20 publications with PPIB and LEPRE1
SERPINH1 active protein	>9 publications with PPIB and SERPINH1
PDIA3 active protein	>1 publications with PPIB and PDIA3
FKBP2 active protein	>1 publications with PPIB and FKBP2

Pathways associated with PPIB active protein

Products by Pathway	Pathway Diagram
Collagen Biosynthesis And Modifying Enzymes Pathway antibodies	Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Prolactin Signaling Pathway antibodies	Prolactin Signaling Pathway Diagram
Syndecan-1-mediated Signaling Events Pathway antibodies	Syndecan-1-mediated Signaling Events Pathway Diagram

Diseases associated with PPIB active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with PPIB and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with PPIB and Brain Diseases
Breast Neoplasms Antibodies	>2 publications with PPIB and Breast Neoplasms
Inflammation Antibodies	>2 publications with PPIB and Inflammation
Adenocarcinoma Antibodies	>1 publications with PPIB and Adenocarcinoma
Liver Neoplasms Antibodies	>1 publications with PPIB and Liver Neoplasms
Disease Models, Animal Antibodies	>1 publications with PPIB and Disease Models, Animal
Kidney Diseases Antibodies	>1 publications with PPIB and Kidney Diseases
Heart Diseases Antibodies	>1 publications with PPIB and Heart Diseases
Liver Diseases Antibodies	>1 publications with PPIB and Liver Diseases

Organs/Tissues associated with PPIB active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>20 publications with PPIB and Bone
Blood Antibodies	>12 publications with PPIB and Blood
Skin Antibodies	>11 publications with PPIB and Skin
Connective Tissue Antibodies	>6 publications with PPIB and Connective Tissue
Liver Antibodies	>3 publications with PPIB and Liver
Brain Antibodies	>3 publications with PPIB and Brain
Muscle Antibodies	>3 publications with PPIB and Muscle
Kidney Antibodies	>3 publications with PPIB and Kidney
Pancreas Antibodies	>2 publications with PPIB and Pancreas
Heart Antibodies	>2 publications with PPIB and Heart