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DNAX Accessory Molecule-1 (CD226) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2556790

Protein Construction: Recombinant Mouse DNAX Accessory Molecule-1 is produced by our Mammalian expression system and the target gene encoding Glu19-Pro254 is expressed with a 6His tag at the C-terminus.Background: Mouse DNAX accessory molecule-1(DNAM-1) is a… More details

$175 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DNAX Accessory Molecule-1 (Cd226), Active Protein
Full Product Name
Recombinant Mouse DNAX Accessory Molecule-1 Protein
Product Gene Name
Cd226 active protein
Product Synonym Names
CD226 antigen; platelet and T cell activation antigen 1; CD226 molecule; DNAM1 adhesion glycoprotein; DNAM-1; DNAX accessory molecule-1; DNAX accessory molecule 1; PTA1; T lineage-specific activation antigen 1 antigen; CD226; PTA1; TLiSA1
Host
Human Cells
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Molecular Weight
Molecular Mass: 27.6kDa
Actual Protein Molecular Mass: 35-50kDa
3D Structure
ModBase 3D Structure for Q8K4F0
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fragment
Met 1-Pro 254
Fusion Tag
C-6His
Activity
Measured by its binding ability in a functional ELISA. Immobilized mouse DNAM1 at 2 mug/ml (100 mul/well) can bind mouse CD155 with a linear ranger of 6.4-160 ng/ml.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cd226 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cd226 purchase

MBS2556790 is an active protein targeting Cd226. Also known as Recombinant Mouse DNAX Accessory Molecule-1 Protein. Host: Human Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for Cd226. It may not necessarily be applicable to this product.

NCBI GI #
85540456
NCBI GeneID
225825
NCBI Accession #
NP_848802.2
UniProt Primary Accession #
Q8K4F0
UniProt Related Accession #
Q8K4F0
GenBank Nucleotide #
NM_178687.2
NCBI Official Full Name
CD226 antigen isoform a
NCBI Official Synonym Full Names
CD226 antigen
NCBI Official Symbol
Cd226
NCBI Official Synonym Symbols
Pta1; DNAM1; DNAM-1; TLiSA1; BC051526
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
Platelet and T-cell activation antigen 1; CD_antigen: CD226
Protein Family
CD226 antigen
UniProt Gene Name
Cd226
UniProt Synonym Gene Names
Pta1
NCBI Protein Information
CD226 antigen

UniProt Comments for Cd226

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
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Research Articles on Cd226

1. DNAM-1 (CD226) has been associated with specific inhibitory receptors, suggesting that it might be functionally involved in natural killer cell education. The present study shows that DNAM-1 function is associated with natural killer cell education but is not necessary to reach nor maintain the educated state. The authors propose a model in which natural killer cell education prevents or delays downregulation of DNAM-1.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cd226 active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with Cd226 active protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >59 publications with Cd226 and Immune System Diseases
 Nervous System Diseases Antibodies  >13 publications with Cd226 and Nervous System Diseases
 Inflammation Antibodies  >12 publications with Cd226 and Inflammation
 Respiratory Tract Diseases Antibodies  >11 publications with Cd226 and Respiratory Tract Diseases
 Necrosis Antibodies  >11 publications with Cd226 and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with Cd226 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with Cd226 and Diabetes Mellitus, Type 1
 Colorectal Neoplasms Antibodies  >7 publications with Cd226 and Colorectal Neoplasms
 Immunologic Deficiency Syndromes Antibodies  >5 publications with Cd226 and Immunologic Deficiency Syndromes
 Breast Neoplasms Antibodies  >4 publications with Cd226 and Breast Neoplasms

Organs/Tissues associated with Cd226 active protein

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >27 publications with Cd226 and Other
 Bone Antibodies  >11 publications with Cd226 and Bone
 Lung Antibodies  >6 publications with Cd226 and Lung
 Thymus Antibodies  >3 publications with Cd226 and Thymus
 Spleen Antibodies  >3 publications with Cd226 and Spleen
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