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FGF21 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8120574

Background: Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic… More details

$310 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGF21, Active Protein
Full Product Name
FGF21 Protein, Human, Recombinant (His Tag)
Product Gene Name
FGF21 active protein
Product Synonym Names
Human FGF21 Protein (His Tag); UNQ3115/PRO10196 Protein, Human; fibroblast growth factor 21
Sequence
His29-Ser2 09
Host
E Coli
Form/Format
Lyophilized from 50mM Tris, 10% glycerol, 0.05% Brij 35, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Purity/Purification
>95% as determined by SDS-PAGE
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Molecular Weight
22,300 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (49259344..49261582). Location: 19q13.33
OMIM
609436
3D Structure
ModBase 3D Structure for Q9NSA1
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Activity
Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.1-1ug/mL in the presence of 2.5ug/mL of rmKlotho beta.
Predicted N Terminal
Met
Tag
N-His
Protein Construction
A DNA sequence encoding the mature form of human FGF21 (NP_061986.1)(His 29-Ser 209) was expressed, with a polyhistide tag at the N-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SDS-Page of FGF21 active protein

FGF21 Active Protein – Cat# MBS8120574

Testing Data of FGF21 active protein

Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.1--1 ug/mL in the presence of 2.5 ug/mL of rmKlotho beta.
FGF21 Active Protein, Testing Data – Cat# MBS8120574

Product References and Citations for FGF21 active protein

Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.Lunda¥sen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.

Other Notes

Small volumes of FGF21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF21 purchase

MBS8120574 is an active protein targeting FGF21. Also known as FGF21 Protein, Human, Recombinant (His Tag). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF21. It may not necessarily be applicable to this product.

NCBI GI #
9506597
NCBI GeneID
26291
NCBI Accession #
NP_061986.1
UniProt Primary Accession #
Q9NSA1
UniProt Secondary Accession #
Q8N683
UniProt Related Accession #
Q9NSA1
GenBank Nucleotide #
NM_019113.2
NCBI Official Full Name
fibroblast growth factor 21
NCBI Official Synonym Full Names
fibroblast growth factor 21
NCBI Official Symbol
FGF21
UniProt Protein Name
Fibroblast growth factor 21
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF21
UniProt Synonym Gene Names
FGF-21
UniProt Entry Name
FGF21_HUMAN
NCBI Protein Information
fibroblast growth factor 21; FGF-21

NCBI Summary for FGF21

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF21

FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction
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Research Articles on FGF21

1. The results suggest that FGF-21 is related to BMI but not disease activity or lipid profiles in patients with RA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF21 active protein

 Reference Product  PubMed Publications
 PPARG active protein  >27 publications with FGF21 and PPARG
 FGFR1 active protein  >24 publications with FGF21 and FGFR1
 KLB active protein  >21 publications with FGF21 and KLB
 FGFR4 active protein  >13 publications with FGF21 and FGFR4
 FGFR2 active protein  >7 publications with FGF21 and FGFR2
 AKT1 active protein  >4 publications with FGF21 and AKT1
 FGFR3 active protein  >4 publications with FGF21 and FGFR3
 CYP7A1 active protein  >3 publications with FGF21 and CYP7A1
 INS active protein  >1 publications with FGF21 and INS

Pathways associated with FGF21 active protein

 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with FGF21 active protein

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >97 publications with FGF21 and Insulin Resistance
 Fatty Liver Antibodies  >92 publications with FGF21 and Fatty Liver
 Diabetes Mellitus, Type 2 Antibodies  >51 publications with FGF21 and Diabetes Mellitus, Type 2
 Liver Diseases Antibodies  >51 publications with FGF21 and Liver Diseases
 Inflammation Antibodies  >25 publications with FGF21 and Inflammation
 Hyperglycemia Antibodies  >25 publications with FGF21 and Hyperglycemia
 Weight Loss Antibodies  >25 publications with FGF21 and Weight Loss
 Cardiovascular Diseases Antibodies  >19 publications with FGF21 and Cardiovascular Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >19 publications with FGF21 and Non-alcoholic Fatty Liver Disease
 Kidney Diseases Antibodies  >15 publications with FGF21 and Kidney Diseases

Organs/Tissues associated with FGF21 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with FGF21 and Lung
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