Fibroblast Growth Factor 19 (FGF19) Active Protein

Name: FGF19 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650885
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650885

MBS650885 is an active protein targeting FGF19. Also known as Fibroblast Growth Factor 19, Recombinant, Human (FGF19). More details

$640 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Fibroblast Growth Factor 19 (FGF19), Active Protein

Full Product Name

Fibroblast Growth Factor 19, Recombinant, Human (FGF19)

Product Gene Name

FGF19 active protein

Form/Format

Supplied as a lyophilized powder in 5mM Tris, pH 7.6, 75mM sodium chloride. Sterile-filtered prior to lyophilization. Reconstitute with sterile ddH2O to 0.1-1mg/ml.

Purity/Purification

Highly Purified
~95% (SDS-PAGE, HPLC). Purified by sequential chromatography.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, 0.1-1% BSA, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

24,003 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (69513006..69519106, complement). Location: 11q13.1

OMIM

603891

3D Structure

ModBase 3D Structure for O95750

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

FGF-19 is a high affinity heparin dependent ligand for FGFR4. Embryonic regions known to express FGF-19 include skin, cartilage, retina, gall bladder and small intestine.

Endotoxin Level

~0.1ng/ug

Product Categories/Family for FGF19 active protein

Growth Factors; Cytokines; Growth Factors-FGF

Other Notes

Small volumes of FGF19 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF19. It may not necessarily be applicable to this product.

NCBI GI #

5668601

NCBI GeneID

9965

UniProt Primary Accession #

O95750

UniProt Related Accession #

O95750

NCBI Official Full Name

fibroblast growth factor 19

NCBI Official Synonym Full Names

fibroblast growth factor 19

NCBI Official Symbol

FGF19

UniProt Protein Name

Fibroblast growth factor 19

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF19

UniProt Entry Name

FGF19_HUMAN

NCBI Protein Information

fibroblast growth factor 19; FGF-19; OTTHUMP00000237182

NCBI Summary for FGF19

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq]

UniProt Comments for FGF19

Function: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. Ref.7 Ref.8 Ref.10

Subunit structure: Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Ref.2 Ref.9

Subcellular location: Secreted.

Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. Ref.2

Induction: Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2. Ref.7

Miscellaneous: Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Research Articles on FGF19

1. FGFR4 activation mediates the induction of hepatocyte proliferation and the suppression of bile acid biosynthesis by FGF19.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF19 active protein

Reference Product	PubMed Publications
FGFR4 active protein	>34 publications with FGF19 and FGFR4

Pathways associated with FGF19 active protein

Products by Pathway	Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGF Signaling Pathway antibodies	FGF Signaling Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram
FGFR4 Ligand Binding And Activation Pathway antibodies	FGFR4 Ligand Binding And Activation Pathway Diagram
FRS2-mediated Cascade Pathway antibodies	FRS2-mediated Cascade Pathway Diagram
IRS-mediated Signalling Pathway antibodies	IRS-mediated Signalling Pathway Diagram
IRS-related Events Pathway antibodies	IRS-related Events Pathway Diagram
Insulin Receptor Signalling Cascade Pathway antibodies	Insulin Receptor Signalling Cascade Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram

Diseases associated with FGF19 active protein

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>9 publications with FGF19 and Carcinoma, Hepatocellular

Organs/Tissues associated with FGF19 active protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>13 publications with FGF19 and Intestine
Brain Antibodies	>10 publications with FGF19 and Brain
Embryonic Tissue Antibodies	>8 publications with FGF19 and Embryonic Tissue
Parathyroid Antibodies	>3 publications with FGF19 and Parathyroid
Uterus Antibodies	>1 publications with FGF19 and Uterus