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FKBPL Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203550

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance and it… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FKBPL, Active Protein
Full Product Name
FKBPL, 1-349aa, Human, His tag, E Coli (Bioactivity Validated)
Product Gene Name
FKBPL active protein
Product Synonym Names
FK506 binding protein like; DIR1; NG7; WISP39; WAF-1/CIP1 stabilizing protein 39; WISP-39; WISP 39; NG-7; NG 7; DIR-1; DIR 1
Sequence
METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFGL EHHHHHH
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.25 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
39.2kDa (357aa), confirmed by MALDI-TOF
3D Structure
ModBase 3D Structure for Q9UIM3
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Tag Information
His-tag
Biological Activity
Specific activity is > 210 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
Assay
1. Prepare 170ul assay buffer into a suitable container and pre-chill on ice before use: The final concentrations are 200 mM Tris-Hcl, pH 8.0, and 20nM chymotrypsin.
2. Add 10ul of recombinant FKBPL protein with 1ug in assay buffer.
3. Mix by inversion and equilibrate to 1C and monitor the A405nm until the value is constant using a spectrophotometer.
4. Add 20ul pre-chilled 5mM suc-AAFP-pNA. (Substrate was dissolved in TFE that contained 460mM LiCl to a concentration of 3 mM)
5. Record the increase in A405 nm for 30 minutes at 25C.

Product Categories/Family for FKBPL active protein

Heat Shock Proteins
Applications Tested/Suitable for FKBPL active protein
SDS-PAGE

SDS-Page of FKBPL active protein

FKBPL Active Protein – Cat# MBS203550

Product References and Citations for FKBPL active protein

McKeen HD., et al. (2008) Endocrinology 149: 5724.; Jascur T., et al (2005) Mol. Cell 17 (2): 237-49.;

Other Notes

Small volumes of FKBPL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBPL purchase

MBS203550 is an active protein targeting FKBPL. Also known as FKBPL, 1-349aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBPL. It may not necessarily be applicable to this product.

NCBI GI #
17149853
NCBI GeneID
63943
NCBI Accession #
NP_071393
UniProt Primary Accession #
Q9UIM3
UniProt Secondary Accession #
Q9H5G3; A8K5V3; B0UYX8
UniProt Related Accession #
Q9UIM3
GenBank Nucleotide #
NM_022110.3
NCBI Official Full Name
FK506-binding protein-like
NCBI Official Synonym Full Names
FK506 binding protein like
NCBI Official Symbol
FKBPL
NCBI Official Synonym Symbols
NG7; DIR1; FKBP4; WISP39
UniProt Protein Name
FK506-binding protein-like
UniProt Synonym Protein Names
WAF-1/CIP1 stabilizing protein 39; WISp39
Protein Family
FK506-binding protein
UniProt Gene Name
FKBPL
UniProt Synonym Gene Names
DIR1; NG7; WISp39
NCBI Protein Information
FK506-binding protein-like

NCBI Summary for FKBPL

The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
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UniProt Comments for FKBPL

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Research Articles on FKBPL

1. This study identified two low-frequency nonsynonymous variants at FKBPL (rs200847762, OR = 0.34, 95% CI = 0.20-0.57, P = 4.31 x 10-5) and ARPC1B (rs1045012, OR = 0.56, 95% CI = 0.43-0.74, P = 4.30 x 10-5) associated with breast cancer risk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKBPL active protein

 Reference Product  PubMed Publications
 CDKN1A active protein  >6 publications with FKBPL and CDKN1A
 GTSE1 active protein  >1 publications with FKBPL and GTSE1

Pathways associated with FKBPL active protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 The Role Of GTSE1 In G2/M Progression After G2 Checkpoint Pathway antibodies  The Role Of GTSE1 In G2/M Progression After G2 Checkpoint Pathway Diagram

Diseases associated with FKBPL active protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with FKBPL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with FKBPL and Neoplasms, Experimental
 Infertility, Male Antibodies  >2 publications with FKBPL and Infertility, Male
 Carcinoma Antibodies  >1 publications with FKBPL and Carcinoma
 Nervous System Diseases Antibodies  >1 publications with FKBPL and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with FKBPL and Lung Neoplasms

Organs/Tissues associated with FKBPL active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with FKBPL and Lung
 Prostate Antibodies  >1 publications with FKBPL and Prostate
 Testis Antibodies  >1 publications with FKBPL and Testis
 Embryonic Tissue Antibodies  >1 publications with FKBPL and Embryonic Tissue
 Brain Antibodies  >1 publications with FKBPL and Brain
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