Fms (csf1ra) Active Protein

Function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Activates several signaling pathways in response to ligand binding

By similarity. Ref.1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. CSF1 binding leads to dimerization and activation by autophosphorylation on tyrosine residues

By similarity.

Subunit structure: Monomer. Homodimer. Interacts with CSF1

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Note: The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation

By similarity.

Domain: The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase

By similarity.The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase

By similarity.

Post-translational modification: Autophosphorylated in response to CSF1 binding

By similarity. autophosphorylation, leading to its degradation

By similarity.Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.