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GDF11 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Popular Catalog #: MBS538017

GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between… More details

$685 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GDF11, Active Protein
Full Product Name
GDF11 protein
Product Gene Name
GDF11 active protein
Product Synonym Names
BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF11; GDF 11
Sequence
Region of GDF11 protein correspond ing to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.
Host
E. coli
Form/Format
Sterile Filtered through a 0.2 micron filter. Lyophilized with no additives. Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Keep pH below 5.0. Do not vortex.
Purity/Purification
> 98% by SDS-PAGE analysis and HPLC
Concentration
20 ug per vial: lyophilized (lot specific)
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at -20°C. After reconstituted, the undiluted solution is stable at 4°C for up to 1 week. For extended storage, dilute further in a buffer containing a carrier protein (0.1% BSA) and store in working aliquots at -20°C to -80°C. Avoid repeat freeze-thaw cycles.
Molecular Weight
25kDa
OMIM
603936
3D Structure
ModBase 3D Structure for O95390
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Grade
Recombinant
Species
Human
Contaminants
Endotoxin level is <0.1ng/ug
Biological Activity
The biological activity is determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 cells. The ED50 for this effect is 8 to 10 ng/ml.
Biohazard
Use normal laboratory precautions and techniques when handling this reagent.

Product Categories/Family for GDF11 active protein

Cytokines & Growth Factors
Applications Tested/Suitable for GDF11 active protein
User optimized.

Other Notes

Small volumes of GDF11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF11 purchase

MBS538017 is an active protein targeting GDF11. Also known as GDF11 protein. Host: E. coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF11. It may not necessarily be applicable to this product.

NCBI GI #
5031613
NCBI GeneID
10220
NCBI Accession #
NP_005802.1
UniProt Primary Accession #
O95390
UniProt Secondary Accession #
Q9UID1; Q9UID2
UniProt Related Accession #
O95390
GenBank Nucleotide #
NM_005811.3
NCBI Official Full Name
growth/differentiation factor 11
NCBI Official Synonym Full Names
growth differentiation factor 11
NCBI Official Symbol
GDF11
NCBI Official Synonym Symbols
BMP11; BMP-11
UniProt Protein Name
Growth/differentiation factor 11
UniProt Synonym Protein Names
Bone morphogenetic protein 11; BMP-11
Protein Family
Growth/differentiation factor
UniProt Gene Name
GDF11
UniProt Synonym Gene Names
BMP11; GDF-11; BMP-11
UniProt Entry Name
GDF11_HUMAN
NCBI Protein Information
growth/differentiation factor 11

NCBI Summary for GDF11

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
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UniProt Comments for GDF11

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth
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Research Articles on GDF11

1. Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GDF11 active protein

 Reference Product  PubMed Publications
 WFIKKN2 active protein  >4 publications with GDF11 and WFIKKN2
 ACVR2B active protein  >3 publications with GDF11 and ACVR2B
 ACVR1C active protein  >2 publications with GDF11 and ACVR1C
 ACVR1B active protein  >2 publications with GDF11 and ACVR1B
 MAFA active protein  >1 publications with GDF11 and MAFA
 FOXG1 active protein  >1 publications with GDF11 and FOXG1
 PAX6 active protein  >1 publications with GDF11 and PAX6
 ATOH7 active protein  >1 publications with GDF11 and ATOH7

Diseases associated with GDF11 active protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with GDF11 and Disease Models, Animal
 Atrophy Antibodies  >3 publications with GDF11 and Atrophy
 Kidney Diseases Antibodies  >3 publications with GDF11 and Kidney Diseases
 Brain Diseases Antibodies  >2 publications with GDF11 and Brain Diseases
 Anemia, Hemolytic Antibodies  >2 publications with GDF11 and Anemia, Hemolytic
 Urogenital Abnormalities Antibodies  >1 publications with GDF11 and Urogenital Abnormalities
 Hyperplasia Antibodies  >1 publications with GDF11 and Hyperplasia
 Fatty Liver Antibodies  >1 publications with GDF11 and Fatty Liver
 Pain Antibodies  >1 publications with GDF11 and Pain
 Inflammation Antibodies  >1 publications with GDF11 and Inflammation

Organs/Tissues associated with GDF11 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >81 publications with GDF11 and Bone
 Muscle Antibodies  >35 publications with GDF11 and Muscle
 Blood Antibodies  >20 publications with GDF11 and Blood
 Embryonic Tissue Antibodies  >16 publications with GDF11 and Embryonic Tissue
 Heart Antibodies  >11 publications with GDF11 and Heart
 Nerve Antibodies  >11 publications with GDF11 and Nerve
 Kidney Antibodies  >9 publications with GDF11 and Kidney
 Brain Antibodies  >9 publications with GDF11 and Brain
 Eye Antibodies  >6 publications with GDF11 and Eye
 Liver Antibodies  >5 publications with GDF11 and Liver
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