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GOT2 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201147

GOT2, also known aspartate aminotransferase, mitochondrial, belongs to the class-I Pyridoxal-phosphate-dependent aminotransferase family. Glutamate oxaloacetate transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GOT2, Active Protein
Full Product Name
Recombinant GOT2
Product Gene Name
GOT2 active protein
Product Synonym Names
AATM_HUMAN; AL022787; Aspartate aminotransferase; Aspartate aminotransferase 2; Aspartate aminotransferase; mitochondrial; Aspartate transaminase 2; ASPATA; EC 2.6.1.1; FABP 1; FABP pm; FABP-1; FABPpm; Fatty acid binding protein; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; Glutamate oxaloacetate transaminase 2; mitochondrial; Glutamate oxaloacetate transaminase; mitochondrial; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2); Got 2; GOT2; KAT4; KATIV; kynurenine aminotransferase 4; Kynurenine aminotransferase IV; kynurenine-oxoglutarate transaminase 4; kynurenine-oxoglutarate transaminase IV; mAspAT; MGC102129; MGC115763; mitAAT; mitochondrial; Mitochondrial aspartate aminotransferase; OTTMUSP00000017748; Plasma membrane fatty acid binding protein; Plasma membrane-associated fatty acid-binding protein; Transaminase A
Sequence
MGSSHHHHHH SSGLVPRGSH M SSWWTHVEM GPPDPILGVT EAFKRDTNSK KMNLGVGAYR DDNGKPYVLP SVRKAEAQIA AKNLDKEYLP IGGLAEFCKA SAELALGENN EVLKSGRFVT VQTISGTGAL RVGASFLQRF FKFSRDVFLP KPSWGNHTPI FRDAGMQLQG YRYYDPKTCG FDFSGALEDI SKIPEQSVLL LHACAHNPTG VDPRPEQWKE IASVVKKKNL FAFFDMAYQG FASGDGDKDA WAVRHFIEQG INVCLCQSYA KNMGLYGERV GAFTVVCKDA EEAKRVESQL KILIRPLYSN PPLNGARIAA TILTSPDLRK QWLQEVKGMA DRIISMRTQL VSNLKKEGSS HNWQHITDQI GMFCFTGLKP EQVERLTKEF SVYMTKDGRI SVAGVTSGNV GYLAHAIHQV TK
Host
E Coli
Form/Format
Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.
Purity/Purification
>90% by SDS-PAGE
Concentration
0.5mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
46.8 kDa (422aa), confirmed by MALDI-TOF
Sequence Positions
30-430aa
3D Structure
ModBase 3D Structure for P05202
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Mouse
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Tag
His-Tag
Biological Activity
Specific activity is > 20 units/mg, and is defined as the amount of enzyme that converts 1umole of alpha-ketoglutarate to L-Glutamate per minute at pH 8.0 at 25C.

Product Categories/Family for GOT2 active protein

Enzymes & Proteases
Applications Tested/Suitable for GOT2 active protein
SDS-PAGE, Enzyme Activity

SDS-Page of GOT2 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
GOT2 Active Protein – Cat# MBS201147

Product References and Citations for GOT2 active protein

Honorat JA., et al. (2017) PLoS One. 12(11):e0187215. Han Q., et al. (2010) BMC Biochemistry. 11:19.

Other Notes

Small volumes of GOT2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GOT2 purchase

MBS201147 is an active protein targeting GOT2. Also known as Recombinant GOT2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GOT2. It may not necessarily be applicable to this product.

NCBI GI #
6754036
NCBI GeneID
14719
NCBI Accession #
NP_034455.1
UniProt Primary Accession #
P05202
UniProt Related Accession #
P05202
GenBank Nucleotide #
NP_034455.1
NCBI Official Full Name
aspartate aminotransferase, mitochondrial
NCBI Official Synonym Full Names
glutamatic-oxaloacetic transaminase 2, mitochondrial
NCBI Official Symbol
Got2
NCBI Official Synonym Symbols
Got-2; Kyat4; mAspAT; FABP-pm; AL022787
UniProt Protein Name
Aspartate aminotransferase, mitochondrial
UniProt Synonym Protein Names
Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
UniProt Gene Name
Got2
UniProt Synonym Gene Names
Got-2; mAspAT; FABP-1; FABPpm
NCBI Protein Information
aspartate aminotransferase, mitochondrial

UniProt Comments for GOT2

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Research Articles on GOT2

1. GOT2-mediated ATP synthesis may be a pivotal mechanism underlying the protective effect of febuxostat against neurodegeneration in EA

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GOT2 active protein

 Reference Product  PubMed Publications
 Mdh2 active protein  >5 publications with GOT2 and Mdh2
 Mdh1 active protein  >3 publications with GOT2 and Mdh1
 Slc25a13 active protein  >1 publications with GOT2 and Slc25a13

Pathways associated with GOT2 active protein

 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine Biosynthesis Pathway antibodies  Arginine Biosynthesis Pathway Diagram

Diseases associated with GOT2 active protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with GOT2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with GOT2 and Cardiovascular Diseases
 Brain Diseases Antibodies  >4 publications with GOT2 and Brain Diseases
 Mental Disorders Antibodies  >2 publications with GOT2 and Mental Disorders
 Liver Diseases Antibodies  >2 publications with GOT2 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with GOT2 and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with GOT2 and Fatty Liver
 Hypertension Antibodies  >2 publications with GOT2 and Hypertension
 Cardiomyopathies Antibodies  >1 publications with GOT2 and Cardiomyopathies
 Hypertrophy Antibodies  >1 publications with GOT2 and Hypertrophy

Organs/Tissues associated with GOT2 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with GOT2 and Blood
 Liver Antibodies  >6 publications with GOT2 and Liver
 Brain Antibodies  >4 publications with GOT2 and Brain
 Thyroid Antibodies  >3 publications with GOT2 and Thyroid
 Muscle Antibodies  >3 publications with GOT2 and Muscle
 Heart Antibodies  >3 publications with GOT2 and Heart
 Bladder Antibodies  >2 publications with GOT2 and Bladder
 Connective Tissue Antibodies  >1 publications with GOT2 and Connective Tissue
 Spinal Cord Antibodies  >1 publications with GOT2 and Spinal Cord
 Stomach Antibodies  >1 publications with GOT2 and Stomach
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