• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IDO1 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847024

IDO1 is an indoleamine 2; 3-dioxygenase- a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan; and serotonin. It is thought to… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
IDO1, Active Protein
Full Product Name
IDO1; human recombinant
Product Gene Name
IDO1 active protein
Product Synonym Names
Indoleamine 2; 3-dioxygenase 1; IDO; IDO-1; INDO
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAHAMEN SWTISKEYHI DEEVGFALPN PQENLPDFYN DWMFIAKHLP DLIESGQLRE RVEKLNMLSI DHLTDHKSQR LARLVLGCIT MAYVWGKGHG DVRKVLPRNI AVPYCQLSKK LELPPILVYA DCVLANWKKK DPNKPLTYEN MDVLFSFRDG DCSKGFFLVS LLVEIAAASA IKVIPTVFKA MQMQERDTLL KALLEIASCL EKALQVFHQI HDHVNPKAFF SVLRIYLSGW KGNPQLSDGL VYEGFWEDPK EFAGGSAGQS SVFQCFDVLL GIQQTAGGGH AAQFLQDMRR YMPPAHRNFL CSLESNPSVR EFVLSKGDAG LREAYDACVK ALVSLRSYHL QIVTKYILIP ASQQPKENKT SEDPSKLEAK GTGGTDLMNF LKTVRSTTEK SLLKEG
Host
E Coli
Source: Human
Form/Format
Liquid
In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl; 20% glycerol; 1mM DTT
Purity/Purification
>=90%
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
47.7 kDa
OMIM
M34455 mRNA
3D Structure
ModBase 3D Structure for P14902
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Specific activity is > 300 pmol/min/ug, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of L-Tryptophan to N-formyl-Lkynurenine per minute at pH 6.5 at 25C.
Results
>300 pmol/min/ug
Unit Definition
One unit is defined as the amount of enzyme that hydrolyze 1.0 pmole of L-Tryptophan to N-formyl-Lkynurenine per minute at pH 6.5 at 25C.
Applications Tested/Suitable for IDO1 active protein
SDS-PAGE

Other Notes

Small volumes of IDO1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IDO1 purchase

MBS847024 is an active protein targeting IDO1. Also known as IDO1; human recombinant. Host: E Coli
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for IDO1. It may not necessarily be applicable to this product.

NCBI GI #
4504577
NCBI GeneID
3620
NCBI Accession #
NP_002155.1
UniProt Primary Accession #
P14902
UniProt Secondary Accession #
Q540B4; E5RGR8; F6M9T7
UniProt Related Accession #
P14902
GenBank Nucleotide #
NM_002164.5
NCBI Official Full Name
indoleamine 2,3-dioxygenase 1
NCBI Official Synonym Full Names
indoleamine 2,3-dioxygenase 1
NCBI Official Symbol
IDO1
NCBI Official Synonym Symbols
IDO; INDO; IDO-1
UniProt Protein Name
Indoleamine 2,3-dioxygenase 1
UniProt Synonym Protein Names
Indoleamine-pyrrole 2,3-dioxygenase
Protein Family
Indoleamine 2,3-dioxygenase
UniProt Gene Name
IDO1
UniProt Synonym Gene Names
IDO; INDO; IDO-1
NCBI Protein Information
indoleamine 2,3-dioxygenase 1

NCBI Summary for IDO1

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Show more

UniProt Comments for IDO1

INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family.

Protein type: Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: cytosol

Molecular Function: electron carrier activity; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity

Biological Process: female pregnancy; regulation of activated T cell proliferation; tryptophan catabolic process
Show more

Research Articles on IDO1

1. Together, these results suggest that RSV infection of MSCs alters their immune regulatory function by upregulating IFN-b and IDO, affecting immune cell proliferation, which may account for the lack of protective RSV immunity and for chronicity of RSV-associated lung diseases such as asthma and COPD.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IDO1 active protein

 Reference Product  PubMed Publications
 KYNU active protein  >3 publications with IDO1 and KYNU
 CYP1A1 active protein  >2 publications with IDO1 and CYP1A1
 TPH1 active protein  >2 publications with IDO1 and TPH1
 CYP1A2 active protein  >1 publications with IDO1 and CYP1A2

Pathways associated with IDO1 active protein

 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 L-kynurenine Degradation Pathway antibodies  L-kynurenine Degradation Pathway Diagram
 L-tryptophan Degradation III (eukaryotic) Pathway antibodies  L-tryptophan Degradation III (eukaryotic) Pathway Diagram
 L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
 L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with IDO1 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >68 publications with IDO1 and Inflammation
 Neoplasms, Experimental Antibodies  >12 publications with IDO1 and Neoplasms, Experimental
 Colitis Antibodies  >11 publications with IDO1 and Colitis
 Neurodegenerative Diseases Antibodies  >8 publications with IDO1 and Neurodegenerative Diseases
 Lung Diseases Antibodies  >8 publications with IDO1 and Lung Diseases
 Necrosis Antibodies  >7 publications with IDO1 and Necrosis
 Liver Diseases Antibodies  >6 publications with IDO1 and Liver Diseases
 Breast Neoplasms Antibodies  >6 publications with IDO1 and Breast Neoplasms
 Cognition Disorders Antibodies  >4 publications with IDO1 and Cognition Disorders
 Endometriosis Antibodies  >4 publications with IDO1 and Endometriosis

Organs/Tissues associated with IDO1 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with IDO1 and Brain
 Bone Antibodies  >20 publications with IDO1 and Bone
 Lung Antibodies  >18 publications with IDO1 and Lung
 Liver Antibodies  >12 publications with IDO1 and Liver
 Intestine Antibodies  >8 publications with IDO1 and Intestine
 Uterus Antibodies  >7 publications with IDO1 and Uterus
 Kidney Antibodies  >6 publications with IDO1 and Kidney
 Placenta Antibodies  >6 publications with IDO1 and Placenta
 Embryonic Tissue Antibodies  >4 publications with IDO1 and Embryonic Tissue
 Eye Antibodies  >4 publications with IDO1 and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000