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IFNAR2 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8120229

Background: Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFNAR2, Active Protein
Full Product Name
IFNAR2 Protein, Human, Recombinant (hFc Tag)
Product Gene Name
IFNAR2 active protein
Product Synonym Names
Human IFNAR2/IFNABR Protein (Fc Tag); IFN-alpha-REC Protein, Human; IFN-R Protein, Human; IFNABR Protein, Human; IFNARB Protein, Human; interferon (alpha, beta and omega) receptor 2
Sequence
Met1-Lys24 3
Host
HEK293 Cells
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Purity/Purification
>90% as determined by SDS-PAGE
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Molecular Weight
27,384 Da
OMIM
gene 610424
3D Structure
ModBase 3D Structure for P48551
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Ile 27
Tag
C-human IgG1-Fc
Protein Construction
A DNA sequence encoding the extracellular domain of human IFNAR2 isoform a (NP_997468.1)(Met 1-Lys 243) was fused with the Fc region of human IgG1 at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Activity
1. Measured by its ability to inhibit rh IFNbeta mediated protection of WISH Human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis. The EC50 for this effect is typically 0.2-1.2ug/mL.
2. Measured by its binding ability in a functional ELISA. Immobilized PPICZa-IFNA2 at 10ug/mL (100uL/well) can bind IFNaR2-Fc. The EC50 of IFNaR2-Fc is 60-200ng/mL.

SDS-Page of IFNAR2 active protein

IFNAR2 Active Protein – Cat# MBS8120229

Testing Data of IFNAR2 active protein

Measured by its binding ability in a functional ELISA. Immobilized PPICZa-IFNA2 at 10 ug/mL (100 uL/well) can bind IFNaR2-Fc, the EC50 of IFNaR2-Fc is 60-200 ng/mL.
IFNAR2 Active Protein, Testing Data – Cat# MBS8120229

Product References and Citations for IFNAR2 active protein

Ito K, et al. (2004) Initial expression of interferon alpha receptor 2 (IFNAR2) on CD34-positive cells and its down-regulation correlate with clinical response to interferon therapy in chronic myelogenous leukemia. Eur J Haematol. 73(3): 191-205.Kim SH, et al. (1997) Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2. Gene. 196(1-2): 279-86.Saleh AZ, et al. (2004) Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor. Oncogene. 23(42): 7076-86.

Other Notes

Small volumes of IFNAR2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNAR2 purchase

MBS8120229 is an active protein targeting IFNAR2. Also known as IFNAR2 Protein, Human, Recombinant (hFc Tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR2. It may not necessarily be applicable to this product.

NCBI GI #
46488937
NCBI GeneID
3455
NCBI Accession #
NP_997468.1
UniProt Primary Accession #
P48551
UniProt Secondary Accession #
Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9
UniProt Related Accession #
P48551
GenBank Nucleotide #
NM_207585.2
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform a
NCBI Official Synonym Full Names
interferon alpha and beta receptor subunit 2
NCBI Official Symbol
IFNAR2
NCBI Official Synonym Symbols
IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Synonym Protein Names
Interferon alpha binding protein; Type I interferon receptor 2
Protein Family
Interferon alpha/beta receptor
UniProt Gene Name
IFNAR2
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2
UniProt Entry Name
INAR2_HUMAN
NCBI Protein Information
interferon alpha/beta receptor 2

NCBI Summary for IFNAR2

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for IFNAR2

IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To
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Research Articles on IFNAR2

1. A very small percentage of the pancreatic tumors showed strong expression of the IFNAR-2c.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNAR2 active protein

 Reference Product  PubMed Publications
 IFNA2 active protein  >200 publications with IFNAR2 and IFNA2
 IFNAR1 active protein  >157 publications with IFNAR2 and IFNAR1
 STAT1 active protein  >36 publications with IFNAR2 and STAT1
 STAT2 active protein  >28 publications with IFNAR2 and STAT2
 JAK1 active protein  >26 publications with IFNAR2 and JAK1
 TYK2 active protein  >24 publications with IFNAR2 and TYK2
 GNB2L1 active protein  >2 publications with IFNAR2 and GNB2L1

Diseases associated with IFNAR2 active protein

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >32 publications with IFNAR2 and Liver Diseases
 Carcinoma Antibodies  >26 publications with IFNAR2 and Carcinoma
 Nervous System Diseases Antibodies  >17 publications with IFNAR2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >15 publications with IFNAR2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >11 publications with IFNAR2 and Inflammation
 Liver Neoplasms Antibodies  >9 publications with IFNAR2 and Liver Neoplasms
 Necrosis Antibodies  >9 publications with IFNAR2 and Necrosis
 Hepatitis B Antibodies  >8 publications with IFNAR2 and Hepatitis B
 Cardiovascular Diseases Antibodies  >6 publications with IFNAR2 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >5 publications with IFNAR2 and Kidney Diseases

Organs/Tissues associated with IFNAR2 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with IFNAR2 and Blood
 Liver Antibodies  >35 publications with IFNAR2 and Liver
 Lung Antibodies  >10 publications with IFNAR2 and Lung
 Bone Marrow Antibodies  >7 publications with IFNAR2 and Bone Marrow
 Uterus Antibodies  >7 publications with IFNAR2 and Uterus
 Spleen Antibodies  >7 publications with IFNAR2 and Spleen
 Brain Antibodies  >6 publications with IFNAR2 and Brain
 Kidney Antibodies  >6 publications with IFNAR2 and Kidney
 Lymph Node Antibodies  >3 publications with IFNAR2 and Lymph Node
 Pancreas Antibodies  >3 publications with IFNAR2 and Pancreas
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