IGFBP4 Active Protein

Name: IGFBP4 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS8122637
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8122637

Background: Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as… More details

$475 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IGFBP4, Active Protein

Full Product Name

IGFBP4 Protein, Mouse, Recombinant (His Tag)

Product Gene Name

IGFBP4 active protein

Product Synonym Names

Mouse IGFBP4 Protein (His Tag); AI875747 Protein, Mouse; Deb2 Protein, Mouse; IGFBP-4 Protein, Mouse; insulin-like growth factor binding protein 4

Sequence

Met1-Glu25 4

Host

HEK293 Cells

Form/Format

Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Purity/Purification

>95% as determined by SDS-PAGE

Preparation and Storage

Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.

Molecular Weight

27,807 Da

3D Structure

ModBase 3D Structure for P47879

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mouse

Activity

Measured in a serum free cell proliferation assay using MCF7 human breast adenocarcinoma cells. The ED50 for this effect is typically 0.1-0.6ug/ml

Endotoxin

<1.0EU per ug of the protein as determined by the LAL method

Predicted N Terminal

Asp 22

Tag

C-His

Protein Construction

A DNA sequence encoding the extracellular domain (Met 1-Glu 254) of mouse IGFBP4 (NP_034647.1) precursor was expressed with a C-terminal polyhistidine tag.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Product References and Citations for IGFBP4 active protein

Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82. Karey, K.P. et al. 1988, Cancer Research 48: 4083.

Other Notes

Small volumes of IGFBP4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGFBP4 purchase

MBS8122637 is an active protein targeting IGFBP4. Also known as IGFBP4 Protein, Mouse, Recombinant (His Tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP4. It may not necessarily be applicable to this product.

NCBI GI #

6981086

NCBI GeneID

16010

NCBI Accession #

NP_034647.1

UniProt Primary Accession #

P47879

UniProt Secondary Accession #

O35666; Q3TMV0

UniProt Related Accession #

P47879

GenBank Nucleotide #

NM_010517.3

NCBI Official Full Name

insulin-like growth factor-binding protein 4

NCBI Official Synonym Full Names

insulin-like growth factor binding protein 4

NCBI Official Symbol

Igfbp4

NCBI Official Synonym Symbols

Deb2; IGFBP-4; AI875747

UniProt Protein Name

Insulin-like growth factor-binding protein 4

Protein Family

Insulin-like growth factor-binding protein

UniProt Gene Name

Igfbp4

UniProt Synonym Gene Names

Igfbp-4; IBP-4; IGF-binding protein 4; IGFBP-4

NCBI Protein Information

insulin-like growth factor-binding protein 4

UniProt Comments for IGFBP4

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Research Articles on IGFBP4

1. exerts a negative effect on basal intestinal growth but plays a positive regulatory role in the intestinotropic actions of GLP-2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IGFBP4 active protein

Reference Product	PubMed Publications
Igf1 active protein	>28 publications with IGFBP4 and Igf1
Igfbp1 active protein	>25 publications with IGFBP4 and Igfbp1
Igf2 active protein	>19 publications with IGFBP4 and Igf2
Pappa active protein	>6 publications with IGFBP4 and Pappa
Il6 active protein	>2 publications with IGFBP4 and Il6
Pth active protein	>2 publications with IGFBP4 and Pth
Lrp6 active protein	>1 publications with IGFBP4 and Lrp6

Pathways associated with IGFBP4 active protein

Products by Pathway	Pathway Diagram
Factors And Pathways Affecting Insulin-like Growth Factor (IGF1)-Akt Signaling antibodies	Factors And Pathways Affecting Insulin-like Growth Factor (IGF1)-Akt Signaling Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with IGFBP4 active protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>12 publications with IGFBP4 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>9 publications with IGFBP4 and Cardiovascular Diseases
Inflammation Antibodies	>9 publications with IGFBP4 and Inflammation
Nervous System Diseases Antibodies	>7 publications with IGFBP4 and Nervous System Diseases
Kidney Diseases Antibodies	>5 publications with IGFBP4 and Kidney Diseases
Hypertrophy Antibodies	>5 publications with IGFBP4 and Hypertrophy
Heart Diseases Antibodies	>4 publications with IGFBP4 and Heart Diseases
Atrophy Antibodies	>4 publications with IGFBP4 and Atrophy
Necrosis Antibodies	>4 publications with IGFBP4 and Necrosis
Neoplasms, Experimental Antibodies	>3 publications with IGFBP4 and Neoplasms, Experimental

Organs/Tissues associated with IGFBP4 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>24 publications with IGFBP4 and Blood
Muscle Antibodies	>22 publications with IGFBP4 and Muscle
Ovary Antibodies	>16 publications with IGFBP4 and Ovary
Liver Antibodies	>15 publications with IGFBP4 and Liver
Bone Antibodies	>13 publications with IGFBP4 and Bone
Brain Antibodies	>11 publications with IGFBP4 and Brain
Kidney Antibodies	>10 publications with IGFBP4 and Kidney
Connective Tissue Antibodies	>10 publications with IGFBP4 and Connective Tissue
Heart Antibodies	>8 publications with IGFBP4 and Heart
Embryonic Tissue Antibodies	>7 publications with IGFBP4 and Embryonic Tissue