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IL-21 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201287

IL-21, also known as Interleukin-21, is an important modulator of natural killer (NK) cell function. However, little is known about IL-21 function in canine NK cells because the phenotype of these cells remains undefined. NK cells proliferated rapidly in… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-21, Active Protein
Full Product Name
Recombinant canine IL-21 protein
Product Gene Name
IL-21 active protein
Product Synonym Names
Interleukin-21
Sequence
MHKSSFQEQD LLLIRMRQLI DIVDQLKNYV NDLDPESLPA PEDVKRHCER SAFSCFQKVQ LKAANTGGNE QIINVLTKQL KRKLPPTNAG RRQKHRPACP SCDSYEKAPP KEFLERLKSL IQKMIHQHLS
Host
E Coli
Form/Format
Liquid. In Phosphate-Buffered Saline (pH7.4)
Purity/Purification
>95% by SDS-PAGE
Concentration
0.5mg/ml (determined by absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
16,776 Da
Sequence Positions
18-146aa
3D Structure
ModBase 3D Structure for Q6L7I9
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Species
Canine
Tag
Non-Tagged
Bioactivity
The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. The ED50 range <= 2ng/ml.

Product Categories/Family for IL-21 active protein

Immunology; Proteins
Applications Tested/Suitable for IL-21 active protein
SDS-PAGE, Bioactivity

SDS-Page of IL-21 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
IL-21 Active Protein – Cat# MBS201287

Biological Activity of IL-21 active protein

Canine IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range <= 2 ng/ml.
IL-21 Active Protein, Biological Activity – Cat# MBS201287

Product References and Citations for IL-21 active protein

DJ Shin., et al. (2015) Vet Immunol Immunopathol. 15;165(1-2):22-33. Gui G., et al. (2017) Clin Immunol. 183:266-272. Parrish-Novak J., et al. (2000) Nature. 408(6808):57-63.

Other Notes

Small volumes of IL-21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-21 purchase

MBS201287 is an active protein targeting IL-21. Also known as Recombinant canine IL-21 protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-21. It may not necessarily be applicable to this product.

NCBI GI #
50979194
NCBI GeneID
442935
NCBI Accession #
NP_001003347.1
UniProt Primary Accession #
Q6L7I9
UniProt Related Accession #
Q6L7I9
GenBank Nucleotide #
NM_001003347.1
NCBI Official Full Name
interleukin-21
NCBI Official Symbol
IL21
NCBI Official Synonym Symbols
IL-21
UniProt Protein Name
Interleukin-21
UniProt Gene Name
IL21
UniProt Synonym Gene Names
IL-21
UniProt Entry Name
IL21_CANFA
NCBI Protein Information
interleukin-21

UniProt Comments for IL-21

Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL-21 active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with IL-21 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >101 publications with IL-21 and Inflammation
 Arthritis, Rheumatoid Antibodies  >46 publications with IL-21 and Arthritis, Rheumatoid
 Lupus Erythematosus, Systemic Antibodies  >41 publications with IL-21 and Lupus Erythematosus, Systemic
 Nervous System Diseases Antibodies  >40 publications with IL-21 and Nervous System Diseases
 Colitis Antibodies  >31 publications with IL-21 and Colitis
 Neoplasms, Experimental Antibodies  >30 publications with IL-21 and Neoplasms, Experimental
 Celiac Disease Antibodies  >24 publications with IL-21 and Celiac Disease
 Kidney Diseases Antibodies  >21 publications with IL-21 and Kidney Diseases
 Hypersensitivity Antibodies  >18 publications with IL-21 and Hypersensitivity
 Lung Diseases Antibodies  >16 publications with IL-21 and Lung Diseases
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