Interferon Alpha 1b (IFNA1) Active Protein

Name: IFNA1 Active Protein; Interferon Alpha 1b; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650448
Price: 680 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650448

At least 23 different variants of IFN-alpha are known. The individual proteins have molecular masses between 19-26kD and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between… More details

$680 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interferon alpha 1b (IFNA1), Active Protein

Full Product Name

Interferon alpha 1b, Recombinant, Human (IFNa1b)

Product Gene Name

IFNA1 active protein

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Cys-Asp-Le u-Pro-Glu.

Host

E Coli

Form/Format

Supplied as a powder lyophilized from a solution (1mg/ml) containing HSA and sodium chloride.

Purity/Purification

Highly Purified
98% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.

Preparation and Storage

Can be stored at +4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

Molecular Weight

19392D

Chromosome Location

Chromosome: 9; NC_000009.11 (21440453..21441315). Location: 9p22

OMIM

147578

3D Structure

ModBase 3D Structure for P01562

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Interferon-alpha 1b is fully biologically active when compared to WHO standard. The specific activity as determined in a viral resistance assay using bovine kidney MDBK cells was found to be 1 x 10e8 IU/ mg.

Dimers and Aggregates

1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug)

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm.
2. Analysis by RP-HPLC, using a standard solution of IFN-alpha 1b as a Reference Standard.

Reconstitution

Reconstitute the lyophilized IFN alpha-1b in sterile dH2O to not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for IFNA1 active protein

Growth Factors; Cytokines; Growth Factors-Interferon

Other Notes

Small volumes of IFNA1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNA1 purchase

MBS650448 is an active protein targeting IFNA1. Also known as Interferon alpha 1b, Recombinant, Human (IFNa1b). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNA1. It may not necessarily be applicable to this product.

NCBI GI #

13128950

NCBI GeneID

3439

NCBI Accession #

NP_076918.1

UniProt Primary Accession #

P01562

UniProt Secondary Accession #

Q14605; Q2M1L8; Q52LB8; Q5VYQ2; Q7M4Q1; Q8WZ68; Q9UMJ3; D4Q9M8

UniProt Related Accession #

P01562

GenBank Nucleotide #

NM_024013.2

NCBI Official Full Name

interferon alpha-1/13

NCBI Official Synonym Full Names

interferon, alpha 1

NCBI Official Symbol

IFNA1

NCBI Official Synonym Symbols

IFL; IFN; IFNA@; IFNA13; IFN-ALPHA; IFN-alphaD

UniProt Protein Name

Interferon alpha-1/13

UniProt Synonym Protein Names

Interferon alpha-D

Protein Family

Interferon

UniProt Gene Name

IFNA1

UniProt Synonym Gene Names

IFN-alpha-1/13; LeIF D

UniProt Entry Name

IFNA1_HUMAN

NCBI Protein Information

interferon alpha-1/13; leIF D; IFN-alpha 1b; IFN-alpha-1/13; interferon-alpha1; interferon alpha-D; interferon alpha 1b

NCBI Summary for IFNA1

The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]

UniProt Comments for IFNA1

Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.15

Subcellular location: Secreted.

Polymorphism: Two forms exist; alpha-1a (shown here) and alpha-1b.

Miscellaneous: Interferons alpha-1 and alpha-13 have identical protein sequences.

Sequence similarities: Belongs to the alpha/beta interferon family.

Research Articles on IFNA1

1. Data indicate that suppressor of IKKepsilon (SIKE) inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNA1 active protein

Reference Product	PubMed Publications
MX1 active protein	>3 publications with IFNA1 and MX1
IRF1 active protein	>2 publications with IFNA1 and IRF1
STAT1 active protein	>1 publications with IFNA1 and STAT1

Pathways associated with IFNA1 active protein

Products by Pathway	Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
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Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Hepatitis B Pathway antibodies	Hepatitis B Pathway Diagram

Diseases associated with IFNA1 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>6 publications with IFNA1 and Necrosis
Neoplasms Antibodies	>4 publications with IFNA1 and Neoplasms
Carcinoma Antibodies	>3 publications with IFNA1 and Carcinoma
Kidney Diseases Antibodies	>3 publications with IFNA1 and Kidney Diseases
Liver Diseases Antibodies	>2 publications with IFNA1 and Liver Diseases
Inflammation Antibodies	>2 publications with IFNA1 and Inflammation
Hepatitis B Antibodies	>2 publications with IFNA1 and Hepatitis B
Weight Loss Antibodies	>1 publications with IFNA1 and Weight Loss
Colorectal Neoplasms Antibodies	>1 publications with IFNA1 and Colorectal Neoplasms
Adenocarcinoma Antibodies	>1 publications with IFNA1 and Adenocarcinoma