Interferon-Inducible T Cell Alpha Chemoattractant (CXCL11) Active Protein

Name: CXCL11 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650538
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650538

CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10). CXCL11 differs from the other CXCR3 ligands in both the strength and the particularities of its receptor interactions: It has a… More details

$370 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interferon-inducible T Cell Alpha Chemoattractant (CXCL11), Active Protein

Full Product Name

Interferon-inducible T Cell Alpha Chemoattractant, Recombinant, Human (I-TAC)

Product Gene Name

CXCL11 active protein

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Phe-Pro-Me t-Phe-Lys.

Host

E Coli

Form/Format

Supplied as a lyophilized powder without additives.

Purity/Purification

Highly Purified
98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

Preparation and Storage

-20 degree C
Stability: Lyophilized I-TAC although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution I-TAC should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Molecular Weight

8.3kD

Chromosome Location

Chromosome: 4; NC_000004.11 (76954835..76957233, complement). Location: 4q21.2

OMIM

604852

3D Structure

ModBase 3D Structure for O14625

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Recombinant Human I-TAC is fully biologically active when compared to standard. The Activity is calculated by the ability to chemoattract IL-2 activated T-cells using a concentration of 0.1-10 ng/ml.

Dimers and Aggregates

Less than 1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug) of Human I-TAC.

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm.
2. Analysis by RP-HPLC, using a calibrated solution of Human I-TAC as a Reference Standard.

Solubility

It is recommended to reconstitute the lyophilized Recombinant Human I-TAC in sterile 18M -cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for CXCL11 active protein

Growth Factors; Cytokines; Growth Factors-I-TAC

Other Notes

Small volumes of CXCL11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL11 purchase

MBS650538 is an active protein targeting CXCL11. Also known as Interferon-inducible T Cell Alpha Chemoattractant, Recombinant, Human (I-TAC). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL11. It may not necessarily be applicable to this product.

NCBI GI #

3219693

NCBI GeneID

6373

UniProt Primary Accession #

O14625

UniProt Secondary Accession #

Q53YA3; Q92840

UniProt Related Accession #

O14625; Q96KF0

NCBI Official Full Name

interferon stimulated T-cell alpha chemoattractant

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 11

NCBI Official Symbol

CXCL11

NCBI Official Synonym Symbols

IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B; MGC102770

UniProt Protein Name

C-X-C motif chemokine 11

UniProt Synonym Protein Names

Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL11

UniProt Synonym Gene Names

ITAC; SCYB11; SCYB9B

UniProt Entry Name

CXL11_HUMAN

NCBI Protein Information

C-X-C motif chemokine 11; beta-R1; OTTHUMP00000160594; OTTHUMP00000219213; OTTHUMP00000219214; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B

NCBI Summary for CXCL11

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq]

UniProt Comments for CXCL11

Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Subcellular location: Secreted.

Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Mass spectrometry: Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. Ref.4

Sequence caution: The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on CXCL11

1. involved in microbial-induced intestinal inflammation and Th17 cell development in ulcerative colitis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL11 active protein

Reference Product	PubMed Publications
CXCR3 active protein	>228 publications with CXCL11 and CXCR3
CCR3 active protein	>8 publications with CXCL11 and CCR3
DPP4 active protein	>1 publications with CXCL11 and DPP4

Pathways associated with CXCL11 active protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with CXCL11 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>124 publications with CXCL11 and Inflammation
Neoplasms Antibodies	>57 publications with CXCL11 and Neoplasms
Necrosis Antibodies	>48 publications with CXCL11 and Necrosis
Liver Diseases Antibodies	>16 publications with CXCL11 and Liver Diseases
Kidney Diseases Antibodies	>15 publications with CXCL11 and Kidney Diseases
Adenocarcinoma Antibodies	>10 publications with CXCL11 and Adenocarcinoma
Neovascularization, Pathologic Antibodies	>9 publications with CXCL11 and Neovascularization, Pathologic
Encephalomyelitis, Autoimmune, Experimental Antibodies	>8 publications with CXCL11 and Encephalomyelitis, Autoimmune, Experimental
Lung Neoplasms Antibodies	>8 publications with CXCL11 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>7 publications with CXCL11 and Neoplasm Metastasis

Organs/Tissues associated with CXCL11 active protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>61 publications with CXCL11 and Lung
Vascular Antibodies	>50 publications with CXCL11 and Vascular
Skin Antibodies	>37 publications with CXCL11 and Skin
Liver Antibodies	>28 publications with CXCL11 and Liver
Intestine Antibodies	>20 publications with CXCL11 and Intestine
Muscle Antibodies	>18 publications with CXCL11 and Muscle
Bone Marrow Antibodies	>16 publications with CXCL11 and Bone Marrow
Mouth Antibodies	>10 publications with CXCL11 and Mouth
Uterus Antibodies	>5 publications with CXCL11 and Uterus
Salivary Gland Antibodies	>3 publications with CXCL11 and Salivary Gland