Interleukin 11 (IL11) Active Protein

Name: IL11 Active Protein; Interleukin 11; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS651008
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS651008

Recombinant Human IL-11 is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19256.29 Dalton. More details

$610 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 11 (IL11), Active Protein

Full Product Name

Interleukin 11, Recombinant, Human (IL-11)

Product Gene Name

IL11 active protein

Form/Format

Supplied as a lyophilized powder. No additives. Reconstitute in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Purity/Purification

Highly Purified
98% by RP-HPLC, anion-exchange FPLC, reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.Endotoxin: 0.1ng/ug (IEU/ug)

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

21,429 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (55875757..55881814, complement). Location: 19q13.3-q13.4

OMIM

147681

3D Structure

ModBase 3D Structure for P20809

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

rHuIL-11 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 was found to be < 10ng/ml, corresponding to a Specific Activity of 1x10e5 IU/mg.

Dimers and Aggregates

1% as determined by silver-stained SDS-PAGE gel analysis.

Endotoxin Level

0.1ng/ug (IEU/ug) of rHuIL-11

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm using the absorbency value of 0.95 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a calibrated solution of IL-11 as a Reference Standard.

Product Categories/Family for IL11 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Other Notes

Small volumes of IL11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL11 purchase

MBS651008 is an active protein targeting IL11. Also known as Interleukin 11, Recombinant, Human (IL-11).

Additional Details

NCBI/Uniprot data below describe general gene information for IL11. It may not necessarily be applicable to this product.

NCBI GI #

10834994

NCBI GeneID

3589

NCBI Accession #

NP_000632.1

UniProt Primary Accession #

P20809

UniProt Secondary Accession #

Q96EB4

UniProt Related Accession #

P20809

GenBank Nucleotide #

NM_000641.2

NCBI Official Full Name

interleukin-11

NCBI Official Synonym Full Names

interleukin 11

NCBI Official Symbol

IL11

NCBI Official Synonym Symbols

AGIF; IL-11

UniProt Protein Name

Interleukin-11

UniProt Synonym Protein Names

Adipogenesis inhibitory factor

Protein Family

Interleukin

UniProt Gene Name

IL11

UniProt Entry Name

IL11_HUMAN

NCBI Protein Information

interleukin-11; oprelvekin; adipogenesis inhibitory factor

NCBI Summary for IL11

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. [provided by RefSeq]

UniProt Comments for IL11

Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

Subcellular location: Secreted.

Pharmaceutical use: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Sequence similarities: Belongs to the IL-6 superfamily.

Research Articles on IL11

1. Interleukin-11, an IL-6 like cytokine

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL11 active protein

Reference Product	PubMed Publications
IL11RA active protein	>88 publications with IL11 and IL11RA

Pathways associated with IL11 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram

Diseases associated with IL11 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>221 publications with IL11 and Neoplasms
Thrombocytopenia Antibodies	>158 publications with IL11 and Thrombocytopenia
Inflammation Antibodies	>123 publications with IL11 and Inflammation
Intestinal Diseases Antibodies	>54 publications with IL11 and Intestinal Diseases
Vascular Diseases Antibodies	>38 publications with IL11 and Vascular Diseases
Edema Antibodies	>29 publications with IL11 and Edema
Fibrosis Antibodies	>28 publications with IL11 and Fibrosis
Liver Diseases Antibodies	>25 publications with IL11 and Liver Diseases
Leukopenia Antibodies	>21 publications with IL11 and Leukopenia
Adenocarcinoma Antibodies	>21 publications with IL11 and Adenocarcinoma

Organs/Tissues associated with IL11 active protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>60 publications with IL11 and Intestine
Connective Tissue Antibodies	>44 publications with IL11 and Connective Tissue
Embryonic Tissue Antibodies	>38 publications with IL11 and Embryonic Tissue
Brain Antibodies	>37 publications with IL11 and Brain
Vascular Antibodies	>37 publications with IL11 and Vascular
Skin Antibodies	>27 publications with IL11 and Skin
Kidney Antibodies	>25 publications with IL11 and Kidney
Stomach Antibodies	>16 publications with IL11 and Stomach
Prostate Antibodies	>9 publications with IL11 and Prostate
Pancreas Antibodies	>6 publications with IL11 and Pancreas