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IP-10 Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS554192

MBS554192 is an active protein targeting IP-10. Also known as Mouse IP-10 Recombinant. Host: E coli (Note: Host protein expression may be lot-specific and can be subject to change during production, including bulk orders.). More details

$240 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IP-10, Active Protein
Full Product Name
Mouse IP-10 Recombinant
Product Gene Name
IP-10 active protein
Sequence
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP
Host
E coli (Note: Host protein expression may be lot-specific and can be subject to change during production, including bulk orders.)
Form/Format
Interleukin-6 was lyophilized from a 0.2 um filtered solution in.5% glycine,.5% sucrose,.01% Tween80, mM Glutamic acid, pH.5.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least years from date of receipt at-20 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
10,789 Da
Chromosome Location
Chromosome: 5; NC_000071.6 (92346638..92348889, complement). Location: 5 E2; 5 46.57 cM
3D Structure
ModBase 3D Structure for P17515
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Source
Optimized DNA sequence encoding Mouse IP-10/CXCL10 mature chain was expressed in Escherichia Coli
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Biological Activity
Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of.1-10.0 ng/ml.
Molecular Function
Cytokine
Biological Process
Chemotaxis, Inflammatory-response
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers

Product Categories/Family for IP-10 active protein

Recombinant Mouse Cytokines; CXC chemokines

Testing Data of IP-10 active protein

Secretion of proinflammatory chemokines by TNF-stimulated glomeruli ex vivo.
Concentrations of CCL2/MCP-1, CCL5/RANTES, and CXCL10/IP-10 were measured by ELISA in culture supernatants of wildtype, Tnfr1?/?, Tnfr2?/?, and Tnfr1,2?/? glomeruli 12 hours after stimulation with 50 ng/ml of TNF.
Mouse IP-10 Active Protein – Cat# MBS554192

Other Notes

Small volumes of IP-10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IP-10. It may not necessarily be applicable to this product.

NCBI GI #
976159
NCBI GeneID
15945
NCBI Accession #
AAA75249.1
UniProt Primary Accession #
P17515
UniProt Related Accession #
P17515
NCBI Official Full Name
IP-10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_MOUSE
NCBI Protein Information
C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily

UniProt Comments for IP-10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of myoblast differentiation; defense response to virus; positive regulation of cell migration
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Research Articles on IP-10

1. Enterovirus 71 (EV71) infection boosts IP-10 expression to increase gamma interferon and gamma interferon (Mig) levels, infiltration of CD8 T cells, virus clearance in tissues and the survival of mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IP-10 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with IP-10 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >925 publications with IP-10 and Inflammation
 Necrosis Antibodies  >554 publications with IP-10 and Necrosis
 Neoplasms Antibodies  >381 publications with IP-10 and Neoplasms
 Lung Diseases Antibodies  >273 publications with IP-10 and Lung Diseases
 Liver Diseases Antibodies  >175 publications with IP-10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >144 publications with IP-10 and Cardiovascular Diseases
 Fibrosis Antibodies  >106 publications with IP-10 and Fibrosis
 Neoplasms, Experimental Antibodies  >101 publications with IP-10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >73 publications with IP-10 and Kidney Diseases
 Drug Toxicity Antibodies  >55 publications with IP-10 and Drug Toxicity

Organs/Tissues associated with IP-10 active protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >142 publications with IP-10 and Lymph Node
 Spleen Antibodies  >113 publications with IP-10 and Spleen
 Bone Marrow Antibodies  >107 publications with IP-10 and Bone Marrow
 Eye Antibodies  >77 publications with IP-10 and Eye
 Intestine Antibodies  >75 publications with IP-10 and Intestine
 Thymus Antibodies  >50 publications with IP-10 and Thymus
 Embryonic Tissue Antibodies  >47 publications with IP-10 and Embryonic Tissue
 Mammary Gland Antibodies  >6 publications with IP-10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP-10 and Epididymis
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