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sTfR Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9139684

Description: Recombinant Human sTfR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Cys89-Phe760) of human sTfR (Accession #NP_001121620.1) fused with a 6xHis tag at the C-terminus.Background: This protein is a… More details

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Product Overview

Online Datasheet in PDF
Product Name
sTfR, Active Protein
Full Product Name
Recombinant Human sTfR Protein
Product Gene Name
sTfR active protein
Product Synonym Gene Name
TFRC
Product Synonym Names
CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR
Sequence
CKGVEPKTEC ERLAGTESPV REEPGEDFPA ARRLYWDDLK RKLSEKLDST DFTGTIKLLN ENSYVPREAG SQKDENLALY VENQFREFKL SKVWRDQHFV KIQVKDSAQN SVIIVDKNGR LVYLVENPGG YVAYSKAATV TGKLVHANFG TKKDFEDLYT PVNGSIVIVR AGKITFAEKV ANAESLNAIG VLIYMDQTKF PIVNAELSFF GHAHLGTGDP YTPGFPSFNH TQFPPSRSSG LPNIPVQTIS RAAAEKLFGN MEGDCPSDWK TDSTCRMVTS ESKNVKLTVS NVLKEIKILN IFGVIKGFVE PDHYVVVGAQ RDAWGPGAAK SGVGTALLLK LAQMFSDMVL KDGFQPSRSI IFASWSAGDF GSVGATEWLE GYLSSLHLKA FTYINLDKAV LGTSNFKVSA SPLLYTLIEK TMQNVKHPVT GQFLYQDSNW ASKVEKLTLD NAAFPFLAYS GIPAVSFCFC EDTDYPYLGT TMDTYKELIE RIPELNKVAR AAAEVAGQFV IKLTHDVELN LDYERYNSQL LSFVRDLNQY RADIKEMGLS LQWLYSARGD FFRATSRLTT DFGNAEKTDR FVMKKLNDRV MRVEYHFLSP YVSPKESPFR HVFWGSGSHT LPALLENLKL RKQNNGAFNE TLFRNQLALA TWTIQGAANA LSGDVWDIDN EF
Host
HEK293 Cells
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Purity/Purification
>97% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized human TfR Protein at 10 ug/ml (100 ul/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
6xHis tag at the C-terminus

Product Categories/Family for sTfR active protein

CD Antigen
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of sTfR active protein

Recombinant Human sTfR Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at approximately 85 kDa.
Human sTfR Active Protein – Cat# MBS9139684

Other Notes

Small volumes of sTfR active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for sTfR purchase

MBS9139684 is an active protein targeting sTfR. Also known as Recombinant Human sTfR Protein. Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for sTfR. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Related Accession #
P02786
GenBank Nucleotide #
NP_001121620.1
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90
Protein Family
Prophage side tail fiber protein
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for sTfR

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for sTfR

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation
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Research Articles on sTfR

1. TfR1 expression (and VEGF) expression was correlated to shorter overall survival in osteosarcoma patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with sTfR active protein

 Reference Product  PubMed Publications
 HFE active protein  >18 publications with sTfR and HFE
 CD4 active protein  >1 publications with sTfR and CD4

Pathways associated with sTfR active protein

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with sTfR active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with sTfR and Neoplasms
 Iron Metabolism Disorders Antibodies  >28 publications with sTfR and Iron Metabolism Disorders
 Anemia Antibodies  >16 publications with sTfR and Anemia
 Disease Models, Animal Antibodies  >11 publications with sTfR and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >8 publications with sTfR and Anemia, Iron-Deficiency
 Lung Neoplasms Antibodies  >7 publications with sTfR and Lung Neoplasms
 Liver Diseases Antibodies  >6 publications with sTfR and Liver Diseases
 Brain Diseases Antibodies  >5 publications with sTfR and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with sTfR and Breast Neoplasms
 Drug Toxicity Antibodies  >4 publications with sTfR and Drug Toxicity

Organs/Tissues associated with sTfR active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with sTfR and Blood
 Liver Antibodies  >22 publications with sTfR and Liver
 Brain Antibodies  >16 publications with sTfR and Brain
 Intestine Antibodies  >11 publications with sTfR and Intestine
 Lung Antibodies  >10 publications with sTfR and Lung
 Bone Antibodies  >8 publications with sTfR and Bone
 Skin Antibodies  >7 publications with sTfR and Skin
 Kidney Antibodies  >7 publications with sTfR and Kidney
 Embryonic Tissue Antibodies  >6 publications with sTfR and Embryonic Tissue
 Prostate Antibodies  >5 publications with sTfR and Prostate
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