TGFB2 Mouse Active Protein

TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; axon; cytoplasm; extracellular region; basement membrane; trans-Golgi network; endosome; secretory granule

Molecular Function: protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; beta-amyloid binding; punt binding; cytokine activity; protein N-terminus binding; transforming growth factor beta receptor binding; receptor binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart morphogenesis; extracellular matrix organization and biogenesis; collagen fibril organization; catagen; positive regulation of apoptosis; heart development; SMAD protein nuclear translocation; dopamine biosynthetic process; protein amino acid phosphorylation; regulation of apoptosis; hair follicle development; transforming growth factor beta receptor signaling pathway; somatic stem cell division; cell cycle arrest; cell growth; cartilage condensation; response to drug; negative regulation of keratinocyte differentiation; negative regulation of immune response; neuron fate commitment; positive regulation of cell cycle; positive regulation of catagen; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; cardioblast differentiation; positive regulation of protein secretion; response to estrogen stimulus; positive regulation of cell division; regulation of MAPKKK cascade; activation of protein kinase activity; neuron development; response to progesterone stimulus; positive regulation of heart contraction; negative regulation of apoptosis; cell death; axon guidance; wound healing; cell morphogenesis; cardiac muscle cell proliferation; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of neuron apoptosis; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of cell proliferation; embryonic neurocranium morphogenesis; hemopoiesis; positive regulation of integrin biosynthetic process; skeletal development; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; blood vessel development; cell migration; regulation of transforming growth factor-beta2 production; hair follicle morphogenesis; positive regulation of cell adhesion mediated by integrin; glial cell migration; regulation of cell proliferation; eye development; positive regulation of cardioblast differentiation; response to hypoxia; epithelial to mesenchymal transition; blood vessel remodeling; negative regulation of cell growth; positive regulation of cell migration; growth