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TGFBR2 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8120228

Background: TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGFBR2, Active Protein
Full Product Name
TGFBR2 Protein, Human, Recombinant (ECD, His Tag)
Product Gene Name
TGFBR2 active protein
Product Synonym Names
Human TGFBR2 Protein (ECD, His Tag); AAT3 Protein, Human; FAA3 Protein, Human; LDS1B Protein, Human; LDS2 Protein, Human; LDS2B Protein, Human; MFS2 Protein, Human; RIIC Protein, Human; TAAD2 Protein, Human; TGFbeta-RII Protein, Human; TGFR-2 Protein, Human; transforming growth factor, beta receptor II (70/80kDa)
Sequence
Met1-Gln16 6
Host
Baculovirus-Insect Cells
Form/Format
Lyophilized from sterile 20mM PBS, 150mM NaCl, 10% glycerol, 0.5mM TCEP, pH7.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Purity/Purification
>90% as determined by SDS-PAGE
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Molecular Weight
67,457 Da
OMIM
133239
3D Structure
ModBase 3D Structure for P37173
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
<1.0EU per ug protein as determined by the LAL method.
Predicted N Terminal
Thr 23
Tag
C-His
Protein Construction
A DNA sequence encoding the human TGFBR2 (NP_003233.4)(Met1-Gln166) was expressed with a polyhistidine tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10ug/mL (100uL/well) can bind TGFB1-His/Biotin. The EC50 of human TGFB1-His/Biotin is 130-300ng/mL.

SDS-Page of TGFBR2 active protein

TGFBR2 Active Protein – Cat# MBS8120228

Testing Data of TGFBR2 active protein

Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 ug/mL (100 uL/well) can bind TGFB1-His/Biotin, the EC50 of human TGFB1-His/Biotin is 0.50-1.20 ug/mL.
TGFBR2 Active Protein, Testing Data – Cat# MBS8120228

Product References and Citations for TGFBR2 active protein

Yu Y, et al. (2012) MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. Carcinogenesis. 33(1):68-76. Shima K, et al. (2011) TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PLoS One. 6(9):e25062.Biros E, et al. (2011) Meta-analysis of the association between single nucleotide polymorphisms in TGF-beta receptor genes and abdominal aortic aneurysm. Atherosclerosis. 219(1):218-23.

Other Notes

Small volumes of TGFBR2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFBR2 purchase

MBS8120228 is an active protein targeting TGFBR2. Also known as TGFBR2 Protein, Human, Recombinant (ECD, His Tag). Host: Baculovirus-Insect Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFBR2. It may not necessarily be applicable to this product.

NCBI GI #
67782324
NCBI GeneID
7048
NCBI Accession #
NP_003233.4
UniProt Primary Accession #
P37173
UniProt Secondary Accession #
Q15580; Q6DKT6; Q99474; B4DTV5
UniProt Related Accession #
P37173
GenBank Nucleotide #
NM_003242.5
NCBI Official Full Name
TGF-beta receptor type-2 isoform B
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Symbol
TGFBR2
NCBI Official Synonym Symbols
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II
Protein Family
TGF-beta receptor
UniProt Gene Name
TGFBR2
UniProt Synonym Gene Names
TGFR-2; TGF-beta receptor type II; TbetaR-II
UniProt Entry Name
TGFR2_HUMAN
NCBI Protein Information
TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transform

NCBI Summary for TGFBR2

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for TGFBR2

TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.

Protein type: EC 2.7.11.30; Oncoprotein; Membrane protein, integral; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: plasma membrane; integral to membrane; caveola; cytosol; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: lens development in camera-type eye; wound healing; apoptosis; heart development; positive regulation of smooth muscle cell proliferation; myeloid dendritic cell differentiation; gastrulation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; positive regulation of T cell tolerance induction; response to nutrient; aging; response to drug; receptor-mediated endocytosis; blood vessel development; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; in utero embryonic development; embryonic hemopoiesis; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; peptidyl-serine phosphorylation; positive regulation of angiogenesis; gut development; regulation of gene expression; response to mechanical stimulus; response to estrogen stimulus; positive regulation of B cell tolerance induction; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation

Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Loeys-dietz Syndrome 2; Esophageal Cancer
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Research Articles on TGFBR2

1. Results show that epigenetic loss of TGFBR2 expression in prostatic fibroblasts, initiated by interactions with Prostate cancer results in the promoter methylation and silencing of DNA damage repair mediators.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFBR2 active protein

 Reference Product  PubMed Publications
 TGFBR1 active protein  >165 publications with TGFBR2 and TGFBR1
 TGFB1 active protein  >93 publications with TGFBR2 and TGFB1
 SMAD3 active protein  >58 publications with TGFBR2 and SMAD3
 SMAD2 active protein  >52 publications with TGFBR2 and SMAD2
 TGFB2 active protein  >43 publications with TGFBR2 and TGFB2
 SMAD4 active protein  >30 publications with TGFBR2 and SMAD4
 TGFB3 active protein  >18 publications with TGFBR2 and TGFB3
 TGFBR3 active protein  >17 publications with TGFBR2 and TGFBR3
 SMAD7 active protein  >14 publications with TGFBR2 and SMAD7
 ACVRL1 active protein  >9 publications with TGFBR2 and ACVRL1

Pathways associated with TGFBR2 active protein

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with TGFBR2 active protein

 Disease Name  Pubmed Publications
 Aortic Aneurysm Antibodies  >100 publications with TGFBR2 and Aortic Aneurysm
 Marfan Syndrome Antibodies  >91 publications with TGFBR2 and Marfan Syndrome
 Loeys-Dietz Syndrome Antibodies  >82 publications with TGFBR2 and Loeys-Dietz Syndrome
 Carcinoma Antibodies  >82 publications with TGFBR2 and Carcinoma
 Heart Diseases Antibodies  >80 publications with TGFBR2 and Heart Diseases
 Bone Diseases Antibodies  >76 publications with TGFBR2 and Bone Diseases
 Craniofacial Abnormalities Antibodies  >60 publications with TGFBR2 and Craniofacial Abnormalities
 Aortic Aneurysm, Thoracic Antibodies  >54 publications with TGFBR2 and Aortic Aneurysm, Thoracic
 Aneurysm, Dissecting Antibodies  >54 publications with TGFBR2 and Aneurysm, Dissecting
 Microsatellite Instability Antibodies  >50 publications with TGFBR2 and Microsatellite Instability

Organs/Tissues associated with TGFBR2 active protein

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >3 publications with TGFBR2 and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with TGFBR2 and Uncharacterized Tissue
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