Mouse TRAIL Active Protein – Cat# MBS2569961

TRAIL Mouse Active Protein

Name: TRAIL Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS2569961
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2569961

MBS2569961 is an active protein targeting TRAIL. Also known as Recombinant Mouse TRAIL protein (N-His)(active). Host: E Coli. More details

$265 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRAIL, Active Protein

Full Product Name

Recombinant Mouse TRAIL protein (N-His)(active)

Product Gene Name

TRAIL active protein

Product Synonym Names

IL36A; Interleukin-1 family member 6 (IL-1F6); FIL1epsilon (FIL1E); Interleukin-1epsilon (IL1E); Fi; Fil; Fil1; IL-1; IL-1H1; IL1RP2

Sequence

MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ DNYSKIGLAC FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF QDTISTVPEK QLSTPPLPRG GRPQKVAAHI TGITRRSNSA LIPISKDGKT LGQKIESWES SRKGHSFLNH VLFRNGELVI EQEGLYYIYS QTYFRFQEAE DASKMVSKDK VRTKQLVQYI YKYTSYPDPI VLMKSARNSC WSRDAEYGLY SIYQGGLFEL KKNDRIFVSV TNEHLMDLDQ EASFFGAFLI N

Host

E Coli

Form/Format

Lyophilized from sterile PBS, pH 7.4

Purity/Purification

>98% as determined by SDS-PAGE.

Preparation and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
This product is provided as lyophilized powder which is shipped with ice packs.

Molecular Weight

33,477 Da

3D Structure

ModBase 3D Structure for P50592

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mouse

Tag

N-His

Endotoxin

<0.1 EU per 1 ug of the protein by the LAL method.

Activity

Measure by its ability to induce cytotoxicity in L929 cells in the presence of actinomycin D.The ED50 for this effect is <1 ng/mL.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TRAIL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRAIL. It may not necessarily be applicable to this product.

NCBI GI #

6678431

NCBI GeneID

22035

NCBI Accession #

NP_033451.1

UniProt Primary Accession #

P50592

UniProt Related Accession #

P50592

GenBank Nucleotide #

NM_009425.2

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 10

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 10

NCBI Official Symbol

Tnfsf10

NCBI Official Synonym Symbols

TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 10

UniProt Synonym Protein Names

TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

Tnfsf10

UniProt Synonym Gene Names

Trail; Protein TRAIL

UniProt Entry Name

TNF10_MOUSE

NCBI Protein Information

tumor necrosis factor ligand superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand; TRAIL/APO2L

UniProt Comments for TRAIL

TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; immune response

Research Articles on TRAIL

1. TRAIL-deficiency in ApoE(-/-) mice exacerbates nephropathy and insulin resistance

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TRAIL active protein

Reference Product	PubMed Publications
Tnfrsf10b active protein	>2809 publications with TRAIL and Tnfrsf10b
Casp8 active protein	>1306 publications with TRAIL and Casp8
Fadd active protein	>637 publications with TRAIL and Fadd
Cflar active protein	>256 publications with TRAIL and Cflar
Tnfrsf11b active protein	>175 publications with TRAIL and Tnfrsf11b
Ifnar1 active protein	>3 publications with TRAIL and Ifnar1
Prdx4 active protein	>1 publications with TRAIL and Prdx4
Tnfrsf23 active protein	>1 publications with TRAIL and Tnfrsf23
Ifngr1 active protein	>1 publications with TRAIL and Ifngr1

Pathways associated with TRAIL active protein

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Signaling Pathway antibodies	Apoptosis Signaling Pathway Diagram
Caspase-8 Activation By Cleavage Pathway antibodies	Caspase-8 Activation By Cleavage Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Death Receptor Signalling Pathway antibodies	Death Receptor Signalling Pathway Diagram
Dimerization Of Procaspase-8 Pathway antibodies	Dimerization Of Procaspase-8 Pathway Diagram

Diseases associated with TRAIL active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>3875 publications with TRAIL and Necrosis
Leukemia Antibodies	>474 publications with TRAIL and Leukemia
Liver Diseases Antibodies	>343 publications with TRAIL and Liver Diseases
Colorectal Neoplasms Antibodies	>343 publications with TRAIL and Colorectal Neoplasms
Breast Neoplasms Antibodies	>321 publications with TRAIL and Breast Neoplasms
Liver Neoplasms Antibodies	>298 publications with TRAIL and Liver Neoplasms
Lung Neoplasms Antibodies	>293 publications with TRAIL and Lung Neoplasms
Neoplasms, Experimental Antibodies	>290 publications with TRAIL and Neoplasms, Experimental
Inflammation Antibodies	>276 publications with TRAIL and Inflammation
Glioma Antibodies	>251 publications with TRAIL and Glioma

Organs/Tissues associated with TRAIL active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>466 publications with TRAIL and Liver
Lung Antibodies	>394 publications with TRAIL and Lung
Kidney Antibodies	>156 publications with TRAIL and Kidney
Bone Marrow Antibodies	>114 publications with TRAIL and Bone Marrow
Muscle Antibodies	>79 publications with TRAIL and Muscle
Spleen Antibodies	>73 publications with TRAIL and Spleen
Mixed Antibodies	>31 publications with TRAIL and Mixed
Thymus Antibodies	>27 publications with TRAIL and Thymus
Spinal Cord Antibodies	>12 publications with TRAIL and Spinal Cord
Mammary Gland Antibodies	>7 publications with TRAIL and Mammary Gland