TREML2 Active Protein

Name: TREML2 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS635979
Price: 1130 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635979

Tremlike transcript 2 protein (TLT2; also TREML2) is a 33kD (unglycosylated) type I transmembrane cell surface receptor and member of the Trem family of receptor proteins. Human TLT2 is synthesized as a 321aa precursor that contains an 18 aa signal… More details

$1130 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TREML2, Active Protein

Full Product Name

TREML2, Recombinant, Human (Triggering Receptor Expressed on Monocytes Cells-like Protein 2, TREM-like Transcript 2 Protein, TLT-2, C6orf76, TLT2, UNQ6268/PRO20473)

Product Gene Name

TREML2 active protein

Form/Format

Supplied as a lyophilized powder from PBS. Reconstitute with sterile PBS.

Purity/Purification

Highly Purified
~90% (SDS-PAGE, reducing conditions)

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~54kD

Chromosome Location

Chromosome: 6; NC_000006.11 (41157552..41168925, complement). Location: 6p21.1

OMIM

609715

3D Structure

ModBase 3D Structure for Q5T2D2

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

Measured by its ability to inhibit antiCD3induced proliferation of stimulated human T cells. Human PBMC cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with antiCD3 and recombinant human TREML2/Fc Chimera. The ED50 for this effect is typically 0.45-1.8ug/ml.

Endotoxin Level

1EU/1ug (LAL)

Product Categories/Family for TREML2 active protein

Molecular Biology; MB-Proteins

Application Notes for TREML2 active protein

SDS-PAGE: 75-100kD, reducing conditions

Other Notes

Small volumes of TREML2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TREML2 purchase

MBS635979 is an active protein targeting TREML2. Also known as TREML2, Recombinant, Human (Triggering Receptor Expressed on Monocytes Cells-like Protein 2, TREM-like Transcript 2 Protein, TLT-2, C6orf76, TLT2, UNQ6268/PRO20473).

Additional Details

NCBI/Uniprot data below describe general gene information for TREML2. It may not necessarily be applicable to this product.

NCBI GI #

170932501

NCBI GeneID

79865

NCBI Accession #

NP_079083.2

UniProt Primary Accession #

Q5T2D2

UniProt Secondary Accession #

Q08AP8; Q08AP9; Q8IWY0; Q9H8E9

UniProt Related Accession #

Q5T2D2

GenBank Nucleotide #

NM_024807.3

NCBI Official Full Name

trem-like transcript 2 protein

NCBI Official Synonym Full Names

triggering receptor expressed on myeloid cells-like 2

NCBI Official Symbol

TREML2

NCBI Official Synonym Symbols

TLT2; TLT-2; C6orf76; dJ238O23.1

UniProt Protein Name

Trem-like transcript 2 protein

UniProt Synonym Protein Names

Triggering receptor expressed on myeloid cells-like protein 2

Protein Family

Trem-like transcript 2 protein

UniProt Gene Name

TREML2

UniProt Synonym Gene Names

C6orf76; TLT2; TLT-2

UniProt Entry Name

TRML2_HUMAN

NCBI Protein Information

trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like protein 2

NCBI Summary for TREML2

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

UniProt Comments for TREML2

TREML2: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity

Biological Process: T cell activation

Research Articles on TREML2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TREML2 active protein

Reference Product	PubMed Publications
CD276 active protein	>4 publications with TREML2 and CD276
TREM1 active protein	>2 publications with TREML2 and TREM1

Diseases associated with TREML2 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with TREML2 and Neoplasms

Organs/Tissues associated with TREML2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with TREML2 and Blood