Twisted Gastrulation Protein (TWSG1) Active Protein

Name: TWSG1 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS650562
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650562

Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist… More details

$370 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Twisted Gastrulation Protein (TWSG1), Active Protein

Full Product Name

Twisted Gastrulation Protein, Recombinant, Human (TSG)

Product Gene Name

TWSG1 active protein

Host

E Coli

Form/Format

Supplied as a lyophilized powder in 10mM sodium acetate, pH6.0. Reconcentrate with dH2O, carrier protein to a concentration of 0.1-1mg/ml.

Purity/Purification

Highly Purified
98% by SDS-PAGE and HPLC analyses.

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O, carrier protein, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

22kD

Chromosome Location

Chromosome: 18; NC_000018.9 (9334765..9402418). Location: 18p11.3

OMIM

605049

3D Structure

ModBase 3D Structure for Q9GZX9

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is < 2.0 mg/ml of TSG.

Country of Origin

USA

Product Categories/Family for TWSG1 active protein

Growth Factors; Cytokines; Growth Factors-Other

Other Notes

Small volumes of TWSG1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TWSG1 purchase

MBS650562 is an active protein targeting TWSG1. Also known as Twisted Gastrulation Protein, Recombinant, Human (TSG). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TWSG1. It may not necessarily be applicable to this product.

NCBI GI #

10190664

NCBI GeneID

57045

NCBI Accession #

NP_065699.1

UniProt Primary Accession #

Q9GZX9

UniProt Secondary Accession #

Q8NBI7; Q96K46; B2RE08; D3DUH9

UniProt Related Accession #

Q9GZX9

GenBank Nucleotide #

NM_020648.5

NCBI Official Full Name

twisted gastrulation protein homolog 1

NCBI Official Synonym Full Names

twisted gastrulation homolog 1 (Drosophila)

NCBI Official Symbol

TWSG1

NCBI Official Synonym Symbols

TSG

UniProt Protein Name

Twisted gastrulation protein homolog 1

Protein Family

Twisted gastrulation protein

UniProt Gene Name

TWSG1

UniProt Synonym Gene Names

TSG

UniProt Entry Name

TWSG1_HUMAN

NCBI Protein Information

twisted gastrulation protein homolog 1; OTTHUMP00000162352

UniProt Comments for TWSG1

Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development

Subunit structure: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7

Subcellular location: Secreted

Developmental stage: Expressed in brain throughout development. Ref.3

Domain: The N-terminal domain is sufficient to interact with BMP4

Sequence similarities: Belongs to the twisted gastrulation protein family.

Research Articles on TWSG1

1. mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TWSG1 active protein

Reference Product	PubMed Publications
CHRD active protein	>2 publications with TWSG1 and CHRD
BMP1 active protein	>1 publications with TWSG1 and BMP1

Diseases associated with TWSG1 active protein

Disease Name	Pubmed Publications
Craniofacial Abnormalities Antibodies	>4 publications with TWSG1 and Craniofacial Abnormalities
Holoprosencephaly Antibodies	>4 publications with TWSG1 and Holoprosencephaly
Congenital Abnormalities Antibodies	>2 publications with TWSG1 and Congenital Abnormalities
Kidney Diseases Antibodies	>1 publications with TWSG1 and Kidney Diseases
Anemia Antibodies	>1 publications with TWSG1 and Anemia
Thrombosis Antibodies	>1 publications with TWSG1 and Thrombosis
Cardiovascular Diseases Antibodies	>1 publications with TWSG1 and Cardiovascular Diseases
Nervous System Malformations Antibodies	>1 publications with TWSG1 and Nervous System Malformations
Liver Diseases Antibodies	>1 publications with TWSG1 and Liver Diseases
Vascular Diseases Antibodies	>1 publications with TWSG1 and Vascular Diseases

Organs/Tissues associated with TWSG1 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>10 publications with TWSG1 and Bone
Blood Antibodies	>2 publications with TWSG1 and Blood
Embryonic Tissue Antibodies	>2 publications with TWSG1 and Embryonic Tissue
Brain Antibodies	>2 publications with TWSG1 and Brain
Ovary Antibodies	>1 publications with TWSG1 and Ovary
Liver Antibodies	>1 publications with TWSG1 and Liver
Kidney Antibodies	>1 publications with TWSG1 and Kidney
Salivary Gland Antibodies	>1 publications with TWSG1 and Salivary Gland
Vascular Antibodies	>1 publications with TWSG1 and Vascular
Mouth Antibodies	>1 publications with TWSG1 and Mouth