TXN Active Protein

Name: TXN Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203573
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203573

SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in… More details

$220 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TXN, Active Protein

Full Product Name

TXN, 1-105aa, Human, His tag, E Coli (Bioactivity Validated)

Product Gene Name

TXN active protein

Product Synonym Names

Thioredoxin; TRX; TRX1; Thioredoxin JW0871; ECK0879; Thioredoxin reductase; FAD/NAD (P)-binding; TRXR.

Sequence

MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

Host

E Coli

Form/Format

Liquid. In phosphate buffered saline pH7.4

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by BCA assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

13.9 kDa (125aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

OMIM

J04026 mRNA

3D Structure

ModBase 3D Structure for P10599

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Antigen Species

Human

Tag Information

His-tag

Biological Activity

Specific activity is >100 A650/cm/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.

Product Categories/Family for TXN active protein

Redox Proteins

Applications Tested/Suitable for TXN active protein

SDS-PAGE

Product References and Citations for TXN active protein

Pigiet VP., et al. (1986) Proc Natl Acad Sci uSA. 83 (20):7643-7. ; Lundstrom J., et al. (1990) J Biol Chem. 265 (16):9114-20.;

Other Notes

Small volumes of TXN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXN purchase

MBS203573 is an active protein targeting TXN. Also known as TXN, 1-105aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TXN. It may not necessarily be applicable to this product.

NCBI GI #

50592994

NCBI GeneID

7295

NCBI Accession #

NP_003320

UniProt Primary Accession #

P10599

UniProt Secondary Accession #

O60744; Q53X69; Q96KI3; Q9UDG5; B1ALW1

UniProt Related Accession #

P10599

GenBank Nucleotide #

NM_003329.3

NCBI Official Full Name

thioredoxin isoform 1

NCBI Official Synonym Full Names

thioredoxin

NCBI Official Symbol

TXN

NCBI Official Synonym Symbols

TRX; TRDX; TRX1

UniProt Protein Name

Thioredoxin

UniProt Synonym Protein Names

ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

UniProt Gene Name

TXN

UniProt Synonym Gene Names

TRDX; TRX; TRX1; Trx; ADF; SASP

NCBI Protein Information

thioredoxin

NCBI Summary for TXN

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for TXN

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

Research Articles on TXN

1. The ratio of thioredoxin/Keap1 protein level may be useful for suggesting distant metastasis in colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TXN active protein

Reference Product	PubMed Publications
TXNIP active protein	>25 publications with TXN and TXNIP
TXNRD1 active protein	>25 publications with TXN and TXNRD1
MAP3K5 active protein	>16 publications with TXN and MAP3K5
GSR active protein	>12 publications with TXN and GSR
PRDX1 active protein	>11 publications with TXN and PRDX1
SOD1 active protein	>10 publications with TXN and SOD1
PRDX2 active protein	>6 publications with TXN and PRDX2
PRDX5 active protein	>2 publications with TXN and PRDX5
MSRA active protein	>1 publications with TXN and MSRA
TP53 active protein	>1 publications with TXN and TP53

Pathways associated with TXN active protein

Products by Pathway	Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Fluid Shear Stress And Atherosclerosis Pathway antibodies	Fluid Shear Stress And Atherosclerosis Pathway Diagram
Fluid Shear Stress And Atherosclerosis Pathway antibodies	Fluid Shear Stress And Atherosclerosis Pathway Diagram
Folic Acid Network Pathway antibodies	Folic Acid Network Pathway Diagram
Folic Acid Network Pathway antibodies	Folic Acid Network Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with TXN active protein

Disease Name	Pubmed Publications
Death Antibodies	>40 publications with TXN and Death
Inflammation Antibodies	>36 publications with TXN and Inflammation
Lung Diseases Antibodies	>25 publications with TXN and Lung Diseases
Necrosis Antibodies	>20 publications with TXN and Necrosis
Nervous System Diseases Antibodies	>15 publications with TXN and Nervous System Diseases
Lung Neoplasms Antibodies	>12 publications with TXN and Lung Neoplasms
Lung Injury Antibodies	>11 publications with TXN and Lung Injury
Liver Diseases Antibodies	>10 publications with TXN and Liver Diseases
Brain Diseases Antibodies	>9 publications with TXN and Brain Diseases
Heart Diseases Antibodies	>8 publications with TXN and Heart Diseases

Organs/Tissues associated with TXN active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>76 publications with TXN and Blood
Lung Antibodies	>34 publications with TXN and Lung
Vascular Antibodies	>25 publications with TXN and Vascular
Liver Antibodies	>19 publications with TXN and Liver
Heart Antibodies	>18 publications with TXN and Heart
Lymph Antibodies	>18 publications with TXN and Lymph
Lymph Node Antibodies	>17 publications with TXN and Lymph Node
Muscle Antibodies	>16 publications with TXN and Muscle
Brain Antibodies	>14 publications with TXN and Brain
Prostate Antibodies	>11 publications with TXN and Prostate