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VEGF-D Human Cellexp Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847061

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF); which belongs to the PDGF/VEGF growth factor family and is active in angiogenesis; lymphangiogenesis; and endothelial cell growth; stimulating their… More details

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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
VEGF-D, Active Protein
Full Product Name
Human CellExp VEGF-D; Human recombinant
Product Gene Name
VEGF-D active protein
Product Synonym Gene Name
VEGFD
Product Synonym Names
FIGF; VEGFD
Host
HEK 293 cells
Source: Human
Form/Format
Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Normally Trehalose is added as protectant before lyophilization.
Purity/Purification
> 95%
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
13 kDa
OMIM
D89630 mRNA
3D Structure
ModBase 3D Structure for O43915
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 1.0 EU per/mug
Biological Activity
Immobilized Human VEGF R3, Fc Tag at 5mug/mL (100 mul/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 mug/ml.
Binding Capacity
Immobilized Human VEGF R3; Fc Tag at 5mug/mL (100 mul/well) can bind Human VEGF-D; His Tag; Strep Tag with a linear range of 0.08-0.6 mug/ml.
Reconstitution
Reconstitute in sterile deionized water to the desired protein concentration.
Applications Tested/Suitable for VEGF-D active protein
SDS-PAGE, Functional Assay

Other Notes

Small volumes of VEGF-D active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VEGF-D purchase

MBS847061 is an active protein targeting VEGF-D. Also known as Human CellExp VEGF-D; Human recombinant. Host: HEK 293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for VEGF-D. It may not necessarily be applicable to this product.

NCBI GI #
4758378
NCBI GeneID
2277
NCBI Accession #
NP_004460.1
UniProt Primary Accession #
O43915
UniProt Secondary Accession #
B2R7Z3
UniProt Related Accession #
O43915
GenBank Nucleotide #
NM_004469.4
NCBI Official Full Name
vascular endothelial growth factor D preproprotein
NCBI Official Synonym Full Names
vascular endothelial growth factor D
NCBI Official Symbol
VEGFD
NCBI Official Synonym Symbols
FIGF; VEGF-D
UniProt Protein Name
Vascular endothelial growth factor D
UniProt Synonym Protein Names
c-Fos-induced growth factor; FIGF
Protein Family
Vascular endothelial growth factor
UniProt Gene Name
VEGFD
UniProt Synonym Gene Names
VEGF-D; FIGF
NCBI Protein Information
vascular endothelial growth factor D

NCBI Summary for VEGF-D

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
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UniProt Comments for VEGF-D

VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family.

Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: extracellular region; extracellular space

Molecular Function: chemoattractant activity; growth factor activity; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding

Biological Process: angiogenesis; induction of positive chemotaxis; platelet degranulation; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; response to hypoxia; vascular endothelial growth factor receptor signaling pathway
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Research Articles on VEGF-D

1. High VEGFD expression is associated with angiogenesis and lymphangiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VEGF-D active protein

 Reference Product  PubMed Publications
 FLT4 active protein  >4 publications with VEGF-D and FLT4
 FLT1 active protein  >3 publications with VEGF-D and FLT1
 KDR active protein  >2 publications with VEGF-D and KDR
 ALB active protein  >1 publications with VEGF-D and ALB

Pathways associated with VEGF-D active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with VEGF-D active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with VEGF-D and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with VEGF-D and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with VEGF-D and Breast Neoplasms
 Mammary Neoplasms, Animal Antibodies  >2 publications with VEGF-D and Mammary Neoplasms, Animal
 Lung Neoplasms Antibodies  >2 publications with VEGF-D and Lung Neoplasms
 Inflammation Antibodies  >2 publications with VEGF-D and Inflammation
 Weight Gain Antibodies  >1 publications with VEGF-D and Weight Gain
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with VEGF-D and Prenatal Exposure Delayed Effects
 Kidney Diseases Antibodies  >1 publications with VEGF-D and Kidney Diseases
 Insulin Resistance Antibodies  >1 publications with VEGF-D and Insulin Resistance

Organs/Tissues associated with VEGF-D active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with VEGF-D and Lung
 Muscle Antibodies  >4 publications with VEGF-D and Muscle
 Kidney Antibodies  >4 publications with VEGF-D and Kidney
 Heart Antibodies  >3 publications with VEGF-D and Heart
 Mammary Gland Antibodies  >2 publications with VEGF-D and Mammary Gland
 Intestine Antibodies  >2 publications with VEGF-D and Intestine
 Spleen Antibodies  >2 publications with VEGF-D and Spleen
 Liver Antibodies  >2 publications with VEGF-D and Liver
 Uterus Antibodies  >1 publications with VEGF-D and Uterus
 Adrenal Gland Antibodies  >1 publications with VEGF-D and Adrenal Gland
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