CTGF Antibody

Name: CTGF Antibody; MyBioSource
Brand: MyBioSource
SKU: MBS614804
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614804

CTGF is a 38kD, cysteine-rich, secreted peptide. It is a new member of the peptide family that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative proto-oncogene. Among the many functions of the CTGF gene family are… More details

$450 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CTGF, Antibody

Full Product Name

CTGF (Connective Tissue Growth Factor, CCN2, Hcs24, Hypertrophic Chondrocyte-specific Gene Product 24, IGFBP8, Insulin-like Growth Factor-Binding Protein 8)

Product Gene Name

anti-CTGF antibody

Product Synonym Names

Anti -CTGF (Connective Tissue Growth Factor, CCN2, Hcs24, Hypertrophic Chondrocyte-specific Gene Product 24, IGFBP8, Insulin-like Growth Factor-Binding Protein 8)

Isotype

Rabbit IgG

Form/Format

A sterile filtered antibody solution was lyophilized from PBS, pH 7.2

Preparation and Storage

Store at -20°C.

Molecular Weight

Approximately 150kDa

Chromosome Location

Chromosome: 6; NC_000006.11 (132269316..132272518, complement). Location: 6q23.1

OMIM

121009

3D Structure

ModBase 3D Structure for P29279

Preparation

Produced from sera of rabbits immunized with highly pure recombinant Human CTGF. Anti-human CTGF specific antibody was purified by affinity chromatography employing an immobilized Human CTGF matrix.

Immunogen

E.Coli derived recombinant Human CTGF (Please Inquire).

Reconstitution

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0mg/ml.

Product Categories/Family for anti-CTGF antibody

Antibodies; Abs to Growth Factors; Cytokines

Applications Tested/Suitable for anti-CTGF antibody

Immunohistochemistry (IHC), Western Blot (WB), Neutrilization, Sandwich ELISA

Application Notes for anti-CTGF antibody

Immunohistochemistry:
This antibody stained formalin-fixed, paraffin-embedded sections of human breast invasive malignant carcinoma. The recommended concentration is 0.125 ug/mL-0.250 ug/mL with an overnight incubation at 4°C. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended. Optimal concentrations and conditions may vary.
Neutrilization:
To yield one-half maximal inhibition [ND50] of the biological activity of human CTGF (5.0 ug/ml), a concentration of 6.0 - 9.0 ug/ml of this antibody is required.
Sandwich ELISA:
To detect Human CTGF by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human CTGF (MBS695113) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human CTGF.
Western Blot:
To detect Human CTGF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hCTGF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. Optimal dilutions should be determined by each laboratory for each application.

Other Notes

Small volumes of anti-CTGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTGF purchase

MBS614804 is an antibody targeting CTGF. Also known as CTGF (Connective Tissue Growth Factor, CCN2, Hcs24, Hypertrophic Chondrocyte-specific Gene Product 24, IGFBP8, Insulin-like Growth Factor-Binding Protein 8).

Additional Details

NCBI/Uniprot data below describe general gene information for CTGF. It may not necessarily be applicable to this product.

NCBI GI #

4503123

NCBI GeneID

1490

NCBI Accession #

NP_001892.1

UniProt Primary Accession #

P29279

UniProt Secondary Accession #

Q6LCY0; Q96A79; Q96QX2; Q9UDL6; E1P578

UniProt Related Accession #

P29279; Q5M8T4; Q6FHL8

GenBank Nucleotide #

NM_001901.2

NCBI Official Full Name

connective tissue growth factor

NCBI Official Synonym Full Names

connective tissue growth factor

NCBI Official Symbol

CTGF

NCBI Official Synonym Symbols

CCN2; NOV2; HCS24; IGFBP8; MGC102839

UniProt Protein Name

Connective tissue growth factor

UniProt Synonym Protein Names

CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8

Protein Family

Connective tissue growth factor

UniProt Gene Name

CTGF

UniProt Synonym Gene Names

CCN2; HCS24; IGFBP8

UniProt Entry Name

CTGF_HUMAN

NCBI Protein Information

connective tissue growth factor; IBP-8; IGFBP-8; OTTHUMP00000017213; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8

NCBI Summary for CTGF

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq]

UniProt Comments for CTGF

CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; extracellular region; plasma membrane; cell cortex; cytosol

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding

Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of caspase activity; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of cell proliferation; positive regulation of stress fiber formation; response to wounding; response to glucose stimulus; tissue homeostasis; angiogenesis; regulation of cell growth; cell differentiation; cell adhesion; positive regulation of cell activation; cartilage condensation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; ossification; cell migration; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; positive regulation of protein amino acid phosphorylation; regulation of chondrocyte differentiation; positive regulation of cell differentiation; lung development

Research Articles on CTGF

1. CCN2/CTGF is identified as a hepatocellular negative acute phase protein which is down-regulated by IL-6 via the STAT3 pathway through interaction on the DNA binding level

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTGF antibody

Reference Product	PubMed Publications
TGFB1 antibody	>445 publications with CTGF and TGFB1
NOV antibody	>153 publications with CTGF and NOV
TGFB2 antibody	>38 publications with CTGF and TGFB2
TGFB3 antibody	>16 publications with CTGF and TGFB3
VEGFA antibody	>14 publications with CTGF and VEGFA
ERBB4 antibody	>2 publications with CTGF and ERBB4
LRP1 antibody	>1 publications with CTGF and LRP1

Pathways associated with anti-CTGF antibody

Products by Pathway	Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-CTGF antibody

Disease Name	Pubmed Publications
Fibrosis Antibodies	>805 publications with CTGF and Fibrosis
Kidney Diseases Antibodies	>246 publications with CTGF and Kidney Diseases
Neoplasms Antibodies	>231 publications with CTGF and Neoplasms
Inflammation Antibodies	>154 publications with CTGF and Inflammation
Lung Diseases Antibodies	>126 publications with CTGF and Lung Diseases
Pulmonary Fibrosis Antibodies	>101 publications with CTGF and Pulmonary Fibrosis
Liver Diseases Antibodies	>99 publications with CTGF and Liver Diseases
Hypertension Antibodies	>94 publications with CTGF and Hypertension
Diabetic Nephropathies Antibodies	>94 publications with CTGF and Diabetic Nephropathies
Carcinoma Antibodies	>91 publications with CTGF and Carcinoma

Organs/Tissues associated with anti-CTGF antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>1809 publications with CTGF and Connective Tissue
Kidney Antibodies	>419 publications with CTGF and Kidney
Muscle Antibodies	>377 publications with CTGF and Muscle
Vascular Antibodies	>316 publications with CTGF and Vascular
Blood Antibodies	>310 publications with CTGF and Blood
Lung Antibodies	>202 publications with CTGF and Lung
Bone Antibodies	>190 publications with CTGF and Bone
Liver Antibodies	>170 publications with CTGF and Liver
Skin Antibodies	>162 publications with CTGF and Skin
Embryonic Tissue Antibodies	>149 publications with CTGF and Embryonic Tissue