GDC-0980 (Apitolisib)

Name: GDC-0980 (Apitolisib); MyBioSource
Brand: MyBioSource
SKU: MBS3600158
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600158

GDC-0980 (Apitolisib, GNE 390, RG 7422) is a potent, selective, orally available class I PI3K/mTOR inhibitor with IC50 of 5 nM/27 nM/7 nM/14 nM for PI3Kalpha/beta/delta/gamma, inhibits mTOR inhibitor with Ki of 17 nM. More details

$220 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GDC-0980, Biochemical

Full Product Name

GDC-0980

Product Synonym Names

Apitolisib; GNE 390; GDC0980; RG 7422

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

498.6011

Suitability

10mM in DMSO

Target

PI3K

Receptor

mTOR; p110alpha; p110beta; p110gamma; p110delta

Chemical Name

1-Propanone, 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3, 2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-2-hydroxy-, (2S)

SMILES

C[C@H](O)C(N1CCN(CC2=C(C)C3=NC(C4=CN=C(N)N=C4)=NC(N5CCOCC5)=C3S2)CC1)=O

Molecular Formula

C23H30N8O3S

CAS Number

1032754-93-0

Product Categories/Family for GDC-0980 biochemical

Breast Cancer; PI3K/Akt/mTOR signaling; Cancer

Product References and Citations for GDC-0980 biochemical

1. Wallin JJ, et al. Mol Cancer Ther. 2011 Dec; 10 (12):2426-36.
2. Sutherlin DP, et al. J Med Chem. 2011 Nov 10; 54 (21):7579-87.
3. Spoerke JM, Clin Cancer Res. 2012 Dec 15; 18 (24):6771-83.et al.
4. Makhov PB, et al. Mol Cancer Ther. 2012 Jul; 11 (7):1510-7.

Other Notes

Small volumes of GDC-0980 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDC-0980 purchase

MBS3600158 is a biochemical targeting GDC-0980.