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JB170

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5816172

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC 50 =28nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC 50 =193nM) over AURORA-B (EC 50 =1.4uM).… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JB170, Biochemical
Full Product Name
JB170
Product Gene Name
JB170 biochemical
Preparation and Storage
Powder: -20 degree C for 3 years | In solvent: -80 degree C for 1 year
Molecular Weight
963.36
SMILES
O=C(NCCOCCOCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(C=C4OC)NC=5N=CC6=C(N5)C=7C=CC(Cl)=CC7C(=NC6)C=8C(F)=CC=CC8OC
Formula
C48H44ClFN8O11
Solubility
(< 1 mg/ml refers to the product slightly soluble or insoluble)
CAS Number
2705844-82-0

Structure of JB170 biochemical

JB170 Biochemical – Cat# MBS5816172

Other Notes

Small volumes of JB170 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JB170 purchase

MBS5816172 is a biochemical targeting JB170.
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