MPO-IN-1

98%

Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years

2471981-21-0

in plasma MPO assay:2.6 uM, in fluorescent MPO peroxidation assay:0.12 uM

<1mg/ml refers to the product slightly soluble or insoluble

MPO-IN-1 (compound 2)(5 and 90 mg/kg; p.o.; four hours post-Zymosan A administration) significantly reduces MPO activity in a mouse peritonitis model of acute inflammation[1]. Mouse pharmacokinetic parameter of MPO-IN-1[1]. Dose V ss (L/kg) T 1/2 (h) AUC inf (nM/h) p.o. C max (nM) p.o. PPB (%) 1/10 mg/kg i.v./p.o. 9.8 2.6 2486 502 99.6. Animal Model: Male C57BL/6J mice (mouse peritonitis model of acute inflammation)[1]. Dosage: 5 and 90 mg/kg. Administration: p.o. (four hours post-Zymosan A administration). Result: Resulted in a ~50% reduction in the MPO activity at 90 mg/kg.