RB-3

98%

Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years

2396639-11-3

RING1B-BMI1f:2.8 uM (Kd)

<1mg/ml refers to the product slightly soluble or insoluble

RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1]. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 uM[1]. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1]. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. Western Blot Analysis[1]Cell Line: TEX cells. Concentration: 6, 12, 25 uM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPalpha-p42 protein levels.