SR1903 TFA

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor gamma (RORgamma) and liver X receptor (LXR). It is an inverse agonist of RORgamma and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor gamma (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

Small volumes of SR1903 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5812219 is a biochemical targeting SR1903. Also known as SR1903 TFA.