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TRV056

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5801076

TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRV056, Biochemical
Full Product Name
TRV056
Purity/Purification
98%
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
CAS
812644-79-4
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
TRV056 is a "gain-of-function" ligand that have 10-fold greater allosteric coupling to Gq than AngII and is also more efficacious in stimulating cellular Gq-mediated signaling (e.g., IP1 generation). Compared to the endogenous ligand angiotensin II (AngII), "Gq-biased" AT1R agonists are more efficacious in stimulating Gq-mediated cellular signaling and in allosterically promoting Gq coupling[1].

Product References and Citations for TRV056 biochemical

1. Chen et al (2020) Discovery of first-in-class potent and selective tropomyosin receptor kinase degraders. J.Med.Chem. 63 14562 PMID: 33058680

Other Notes

Small volumes of TRV056 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRV056 purchase

MBS5801076 is a biochemical targeting TRV056.
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