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VZ185

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3603644

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VZ185, Biochemical
Full Product Name
VZ185
Product Synonym Names
VZ-185; VZ 185
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
995.225
Target
PROTAC
Receptor
PROTAC
Chemical Name
(2S, 4R)-N-(2-((5-(4-(2, 6-dimethoxy-4-(2-methyl-1-oxo-1, 2-dihydro-2, 7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3, 3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
SMILES
O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5
Molecular Formula
C53H67FN8O8S
CAS Number
2306193-61-1

Product Categories/Family for VZ185 biochemical

PROTACs

Structure of VZ185 biochemical

VZ185 Biochemical – Cat# MBS3603644

Product References and Citations for VZ185 biochemical

1. Zoppi V, et al. J Med Chem. 2018 Dec 12. doi: 10.1021/acs.jmedchem.8b01413.

Other Notes

Small volumes of VZ185 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VZ185 purchase

MBS3603644 is a biochemical targeting VZ185.
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