XVA143

98%

Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years

264275-77-6

<1mg/ml refers to the product slightly soluble or insoluble

XVA143 (1 uM) completely abolishes binding of ICAM-1 to LFA-1 in Mn 2+ and Mg 2+ /EGTA, with no hint of agonism[1]. XVA143 restores rolling of the alpha L -E310A beta 2 mutant by inducing extension of alpha L[2]. Cell Viability Assay[1]Cell Line: K562 cells. Concentration: 0, 0.2, 0.5 and 1 uM. Incubation Time:. Result: Potent against the weakest activator (2 mM Mg 2+ /1 mM EGTA, IC 50 ~10 -3 nM) and least potent against the strongest activator (1 mM Mn 2+, IC 50 ~10 -3 nM). Cell Viability Assay[1]Cell Line: Wild-type murine lymphocytes[1]. Concentration: 100 uM. Incubation Time:. Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27+/-5% to 41+/-7%).