ACK1 Antibody Antigenic Blocking Peptide

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.11.1; Kinase, protein; EC 2.7.10.2; TK group; Ack family

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: adherens junction; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle membrane; endosome; extrinsic to internal side of plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; WW domain binding

Biological Process: cell differentiation; cell migration; cell surface receptor linked signal transduction; endocytosis; innate immune response; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway