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Mouse Acvr1 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9220202

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional… More details

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Product Overview

Online Datasheet in PDF
Product Name
Acvr1, Blocking Peptide
Full Product Name
Mouse Acvr1 Antibody (Center) Blocking peptide
Product Gene Name
Acvr1 blocking peptide
Product Synonym Gene Name
Acvrlk2; Tgfb1
Product Synonym Names
Activin receptor type-1; Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L; Acvr1; Acvrlk2; Tgfb1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of Mouse Acvr1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
Acvr1 peptide (MBS9220202) is used for blocking the activity of Acvr1 antibody (MBS9206850)
Molecular Weight
57,226 Da
Cellular Location
Membrane; Single-pass type I membrane protein
Tissue Location
Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells

Other Notes

Small volumes of Acvr1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Acvr1 purchase

MBS9220202 is a blocking peptide targeting Acvr1. Also known as Mouse Acvr1 Antibody (Center) Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Acvr1. It may not necessarily be applicable to this product.

NCBI GI #
116241240
NCBI GeneID
11477
NCBI Accession #
P37172.2
UniProt Primary Accession #
P37172
UniProt Secondary Accession #
Q3UDH5; Q91VF1
UniProt Related Accession #
P37172
NCBI Official Full Name
Activin receptor type-1
NCBI Official Synonym Full Names
activin A receptor, type 1
NCBI Official Symbol
Acvr1
NCBI Official Synonym Symbols
ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvrlk2; D330013D15Rik
UniProt Protein Name
Activin receptor type-1
UniProt Synonym Protein Names
Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I; TSK-7L
Protein Family
Activin receptor
UniProt Gene Name
Acvr1
UniProt Synonym Gene Names
Acvrlk2; Tgfb1; ACTR-I; SKR1; TSR-I
UniProt Entry Name
ACVR1_MOUSE
NCBI Protein Information
activin receptor type-1

UniProt Comments for Acvr1

ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: activin receptor complex; apical part of cell; integral to plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; growth factor binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I

Biological Process: activin receptor signaling pathway; BMP signaling pathway; determination of left/right symmetry; embryonic development; G1/S transition of mitotic cell cycle; gastrulation; gastrulation with mouth forming second; germ cell development; heart development; in utero embryonic development; mesoderm development; mesoderm formation; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; neural crest cell migration; patterning of blood vessels; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; smooth muscle cell differentiation; transforming growth factor beta receptor signaling pathway; urogenital system development
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Research Articles on Acvr1

1. results suggest that ACVR1(R206H) causes FOP by gaining responsiveness to the normally antagonistic ligand activin A, demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Acvr1 blocking peptide

 Reference Product  PubMed Publications
 Smad1 blocking peptide  >38 publications with Acvr1 and Smad1
 Bmp7 blocking peptide  >27 publications with Acvr1 and Bmp7
 Bmp4 blocking peptide  >26 publications with Acvr1 and Bmp4
 Bmp2 blocking peptide  >26 publications with Acvr1 and Bmp2
 Smad2 blocking peptide  >17 publications with Acvr1 and Smad2
 Smad5 blocking peptide  >12 publications with Acvr1 and Smad5
 Smad3 blocking peptide  >8 publications with Acvr1 and Smad3
 Inhba blocking peptide  >2 publications with Acvr1 and Inhba
 Amh blocking peptide  >2 publications with Acvr1 and Amh
 Smad9 blocking peptide  >1 publications with Acvr1 and Smad9

Pathways associated with Acvr1 blocking peptide

 Products by Pathway  Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with Acvr1 blocking peptide

 Disease Name  Pubmed Publications
 Myositis Ossificans Antibodies  >98 publications with Acvr1 and Myositis Ossificans
 Glioma Antibodies  >24 publications with Acvr1 and Glioma
 Nervous System Diseases Antibodies  >24 publications with Acvr1 and Nervous System Diseases
 Inflammation Antibodies  >14 publications with Acvr1 and Inflammation
 Vascular Diseases Antibodies  >11 publications with Acvr1 and Vascular Diseases
 Death Antibodies  >10 publications with Acvr1 and Death
 Adenocarcinoma Antibodies  >6 publications with Acvr1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with Acvr1 and Breast Neoplasms
 Hypertension Antibodies  >5 publications with Acvr1 and Hypertension
 Astrocytoma Antibodies  >5 publications with Acvr1 and Astrocytoma

Organs/Tissues associated with Acvr1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >34 publications with Acvr1 and Connective Tissue
 Brain Antibodies  >31 publications with Acvr1 and Brain
 Embryonic Tissue Antibodies  >18 publications with Acvr1 and Embryonic Tissue
 Heart Antibodies  >14 publications with Acvr1 and Heart
 Lung Antibodies  >8 publications with Acvr1 and Lung
 Bone Marrow Antibodies  >7 publications with Acvr1 and Bone Marrow
 Eye Antibodies  >5 publications with Acvr1 and Eye
 Spinal Cord Antibodies  >3 publications with Acvr1 and Spinal Cord
 Skin Antibodies  >2 publications with Acvr1 and Skin
 Intestine Antibodies  >1 publications with Acvr1 and Intestine
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