AIF1 Antibody (N-Term) Blocking Peptide

Name: AIF1 Antibody (N-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9217592
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9217592

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AIF1, Blocking Peptide

Full Product Name

AIF1 Antibody (N-term) Blocking Peptide

Product Gene Name

AIF1 blocking peptide

Product Synonym Gene Name

G1; IBA1

Product Synonym Names

Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1; G1; IBA1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

AIF1 peptide (MBS9217592) is used for blocking the activity of AIF1 antibody (MBS9207251)

Molecular Weight

14,617 Da

OMIM

601833

Cellular Location

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis

Tissue Location

Detected in T-lymphocytes and peripheral blood mononuclear cells.

Other Notes

Small volumes of AIF1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIF1 purchase

MBS9217592 is a blocking peptide targeting AIF1. Also known as AIF1 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for AIF1. It may not necessarily be applicable to this product.

NCBI GI #

14574568

NCBI GeneID

199

NCBI Accession #

NP_001614.3

UniProt Primary Accession #

P55008

UniProt Secondary Accession #

O43904; Q9UIV4; Q9UKS9; A8K406

UniProt Related Accession #

P55008

GenBank Nucleotide #

NM_001623.4

NCBI Official Full Name

allograft inflammatory factor 1 isoform 3

NCBI Official Synonym Full Names

allograft inflammatory factor 1

NCBI Official Symbol

AIF1

NCBI Official Synonym Symbols

IBA1; IRT1; AIF-1; IRT-1

UniProt Protein Name

Allograft inflammatory factor 1

UniProt Synonym Protein Names

Ionized calcium-binding adapter molecule 1; Protein G1

Protein Family

Allograft inflammatory factor

UniProt Gene Name

AIF1

UniProt Synonym Gene Names

G1; IBA1; AIF-1

UniProt Entry Name

AIF1_HUMAN

NCBI Protein Information

allograft inflammatory factor 1

NCBI Summary for AIF1

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]

UniProt Comments for AIF1

AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: actin filament; cytoplasm; cytosol; lamellipodium; nucleus; perinuclear region of cytoplasm; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; actin filament polymerization; inflammatory response; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction

Research Articles on AIF1

1. The results of our study suggest that the AIF1 gene polymorphisms have no influence on long-term kidney allograft function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AIF1 blocking peptide

Reference Product	PubMed Publications
GFAP blocking peptide	>142 publications with AIF1 and GFAP
CD68 blocking peptide	>65 publications with AIF1 and CD68
OLIG2 blocking peptide	>13 publications with AIF1 and OLIG2
DCX blocking peptide	>8 publications with AIF1 and DCX
MBP blocking peptide	>7 publications with AIF1 and MBP
TSPO blocking peptide	>5 publications with AIF1 and TSPO
ITGAM blocking peptide	>5 publications with AIF1 and ITGAM
RBFOX3 blocking peptide	>2 publications with AIF1 and RBFOX3
BAG6 blocking peptide	>1 publications with AIF1 and BAG6

Pathways associated with AIF1 blocking peptide

Products by Pathway	Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with AIF1 blocking peptide

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>376 publications with AIF1 and Disease Models, Animal
Inflammation Antibodies	>213 publications with AIF1 and Inflammation
Cardiovascular Diseases Antibodies	>131 publications with AIF1 and Cardiovascular Diseases
Necrosis Antibodies	>113 publications with AIF1 and Necrosis
Nerve Degeneration Antibodies	>55 publications with AIF1 and Nerve Degeneration
Poisoning Antibodies	>24 publications with AIF1 and Poisoning
Neurotoxicity Syndromes Antibodies	>22 publications with AIF1 and Neurotoxicity Syndromes
Learning Disorders Antibodies	>20 publications with AIF1 and Learning Disorders
Parkinson Disease Antibodies	>20 publications with AIF1 and Parkinson Disease
Cognition Disorders Antibodies	>19 publications with AIF1 and Cognition Disorders

Organs/Tissues associated with AIF1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>555 publications with AIF1 and Brain
Blood Antibodies	>187 publications with AIF1 and Blood
Vascular Antibodies	>75 publications with AIF1 and Vascular
Muscle Antibodies	>54 publications with AIF1 and Muscle
Bone Marrow Antibodies	>46 publications with AIF1 and Bone Marrow
Eye Antibodies	>40 publications with AIF1 and Eye
Embryonic Tissue Antibodies	>26 publications with AIF1 and Embryonic Tissue
Heart Antibodies	>24 publications with AIF1 and Heart
Liver Antibodies	>20 publications with AIF1 and Liver
Spleen Antibodies	>19 publications with AIF1 and Spleen