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AKR1D1 Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9632573

MBS9632573 is a blocking peptide targeting AKR1D1. More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AKR1D1, Blocking Peptide
Full Product Name
AKR1D1 Blocking Peptide
Product Gene Name
AKR1D1 blocking peptide
Product Synonym Names
3-oxo-5-beta-steroid 4-dehydrogenase; 3o5bred; AK1D1_HUMAN; AKR1D1; aldo keto reductase family 1 member D1 (delta 4 3 ketosteroid 5 beta reductase); Aldo keto reductase family 1 member D1; Aldo-keto reductase family 1 member D1; CBAS2; Delta(4) 3 ketoster
Antibody/Peptide Pairs
AKR1D1 peptide (MBS9632573) is used for blocking the activity of AKR1D1 antibody (MBS9630190)
Molecular Weight
32,890 Da
OMIM
235555
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AKR1D1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1D1. It may not necessarily be applicable to this product.

NCBI GI #
300116271
NCBI GeneID
6718
NCBI Accession #
NP_001177835.1
UniProt Primary Accession #
P51857
UniProt Secondary Accession #
A1L4P6; A8K060; B4DPN3; B4DPN8
UniProt Related Accession #
P51857
GenBank Nucleotide #
NM_001190906.1
NCBI Official Full Name
3-oxo-5-beta-steroid 4-dehydrogenase isoform 2
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member D1
NCBI Official Symbol
AKR1D1
NCBI Official Synonym Symbols
CBAS2; SRD5B1; 3o5bred
UniProt Protein Name
3-oxo-5-beta-steroid 4-dehydrogenase
UniProt Synonym Protein Names
Aldo-keto reductase family 1 member D1; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase
Protein Family
3-oxo-5-beta-steroid 4-dehydrogenase
UniProt Gene Name
AKR1D1
UniProt Synonym Gene Names
SRD5B1
UniProt Entry Name
AK1D1_HUMAN
NCBI Protein Information
3-oxo-5-beta-steroid 4-dehydrogenase

UniProt Comments for AKR1D1

AKR1D1: Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. Defects in AKR1D1 are the cause of congenital bile acid synthesis defect type 2 (CBAS2); also known as cholestasis with delta(4)-3-oxosteroid 5-beta-reductase deficiency. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine. Belongs to the aldo/keto reductase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.1.3; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q32-q33

Cellular Component: cytosol

Molecular Function: aldo-keto reductase activity; steroid binding

Biological Process: androgen metabolic process; bile acid biosynthetic process; C21-steroid hormone metabolic process; cholesterol catabolic process; digestion

Disease: Bile Acid Synthesis Defect, Congenital, 2
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with AKR1D1 blocking peptide

 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram

Diseases associated with AKR1D1 blocking peptide

 Disease Name  Pubmed Publications
 Cholestasis Antibodies  >7 publications with AKR1D1 and Cholestasis
 Liver Diseases Antibodies  >6 publications with AKR1D1 and Liver Diseases
 Hepatitis Antibodies  >2 publications with AKR1D1 and Hepatitis
 Fatty Liver Antibodies  >2 publications with AKR1D1 and Fatty Liver
 Mental Disorders Antibodies  >1 publications with AKR1D1 and Mental Disorders
 Inflammation Antibodies  >1 publications with AKR1D1 and Inflammation
 Hepatomegaly Antibodies  >1 publications with AKR1D1 and Hepatomegaly
 Hypertrophy Antibodies  >1 publications with AKR1D1 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with AKR1D1 and Hyperplasia
 Hemochromatosis Antibodies  >1 publications with AKR1D1 and Hemochromatosis

Organs/Tissues associated with AKR1D1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with AKR1D1 and Liver
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