AMT Antibody (N-Term) Blocking Peptide

Name: AMT Antibody (N-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9226301
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9226301

MBS9226301 is a blocking peptide targeting AMT. Also known as AMT Antibody (N-term) Blocking Peptide. The glycine cleavage system catalyzes the degradation of glycine. More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMT, Blocking Peptide

Full Product Name

AMT Antibody (N-term) Blocking Peptide

Product Gene Name

AMT blocking peptide

Product Synonym Gene Name

GCST

Product Synonym Names

Aminomethyltransferase; mitochondrial; Glycine cleavage system T protein; GCVT; AMT; GCST

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human AMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

AMT peptide (MBS9226301) is used for blocking the activity of AMT antibody (MBS9211959)

Molecular Weight

41,780 Da

OMIM

238310

Cellular Location

Mitochondrion.

Other Notes

Small volumes of AMT blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AMT. It may not necessarily be applicable to this product.

NCBI GI #

1346122

NCBI GeneID

275

NCBI Accession #

P48728.1

UniProt Primary Accession #

P48728

UniProt Secondary Accession #

Q96IG6; A8K3I5; B4DE61; B4DJQ0; E9PBG1

UniProt Related Accession #

P48728

NCBI Official Full Name

Aminomethyltransferase, mitochondrial

NCBI Official Synonym Full Names

aminomethyltransferase

NCBI Official Symbol

AMT

NCBI Official Synonym Symbols

GCE; NKH; GCST; GCVT

UniProt Protein Name

Aminomethyltransferase, mitochondrial

UniProt Synonym Protein Names

Glycine cleavage system T protein

Protein Family

Probable ammonia channel

UniProt Gene Name

AMT

UniProt Synonym Gene Names

GCVT

UniProt Entry Name

GCST_HUMAN

NCBI Protein Information

aminomethyltransferase, mitochondrial

NCBI Summary for AMT

This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

UniProt Comments for AMT

AMT: The glycine cleavage system catalyzes the degradation of glycine. Defects in AMT are a cause of non-ketotic hyperglycinemia (NKH); also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Belongs to the GcvT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Energy Metabolism - nitrogen; Methyltransferase; Mitochondrial; EC 2.1.2.10; Cofactor and Vitamin Metabolism - one carbon pool by folate

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: aminomethyltransferase activity

Biological Process: glycine catabolic process; glycine decarboxylation via glycine cleavage system; glyoxylate metabolic process

Disease: Glycine Encephalopathy

Research Articles on AMT

1. Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with AMT blocking peptide

Products by Pathway	Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Glycine Degradation Pathway antibodies	Glycine Degradation Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate Metabolism And Glycine Degradation Pathway antibodies	Glyoxylate Metabolism And Glycine Degradation Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram

Diseases associated with AMT blocking peptide

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>133 publications with AMT and Brain Diseases
Cardiovascular Diseases Antibodies	>105 publications with AMT and Cardiovascular Diseases
Inflammation Antibodies	>104 publications with AMT and Inflammation
Vascular Diseases Antibodies	>84 publications with AMT and Vascular Diseases
Heart Diseases Antibodies	>55 publications with AMT and Heart Diseases
Memory Disorders Antibodies	>50 publications with AMT and Memory Disorders
Depressive Disorder Antibodies	>50 publications with AMT and Depressive Disorder
Disease Models, Animal Antibodies	>44 publications with AMT and Disease Models, Animal
Cognition Disorders Antibodies	>39 publications with AMT and Cognition Disorders
Neoplasms, Experimental Antibodies	>32 publications with AMT and Neoplasms, Experimental

Organs/Tissues associated with AMT blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>374 publications with AMT and Blood
Brain Antibodies	>307 publications with AMT and Brain
Eye Antibodies	>204 publications with AMT and Eye
Embryonic Tissue Antibodies	>187 publications with AMT and Embryonic Tissue
Muscle Antibodies	>135 publications with AMT and Muscle
Vascular Antibodies	>81 publications with AMT and Vascular
Bone Antibodies	>81 publications with AMT and Bone
Liver Antibodies	>74 publications with AMT and Liver
Heart Antibodies	>66 publications with AMT and Heart
Kidney Antibodies	>50 publications with AMT and Kidney