APLF Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: APLF Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9614601
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9614601

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APLF, Blocking Peptide

Full Product Name

APLF Blocking Peptide

Product Gene Name

APLF blocking peptide

Product Synonym Names

2010301N04Rik; AI452191; Aplf; APLF_HUMAN; Aprataxin and PNK-like factor; Apurinic-apyrimidinic endonuclease APLF; C2orf13; PNK and APTX like FHA protein; PNK and APTX-like FHA domain-containing protein; RGD1565557; XIP1; XRCC1 interacting protein 1; XRCC1-interacting protein 1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

APLF peptide (MBS9614601) is used for blocking the activity of APLF antibody (MBS9600049)

Molecular Weight

56,956 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (68694691..68807294). Location: 2p13.3

OMIM

611035

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for APLF blocking peptide

Blocking/Control

Other Notes

Small volumes of APLF blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APLF purchase

MBS9614601 is a blocking peptide targeting APLF.

Additional Details

NCBI/Uniprot data below describe general gene information for APLF. It may not necessarily be applicable to this product.

NCBI GI #

27734905

NCBI GeneID

200558

NCBI Accession #

NP_775816.1

UniProt Primary Accession #

Q8IW19

UniProt Secondary Accession #

Q53P47; Q53PB9; Q53QU0; A8K476

UniProt Related Accession #

Q8IW19

GenBank Nucleotide #

NM_173545.2

NCBI Official Full Name

aprataxin and PNK-like factor

NCBI Official Synonym Full Names

aprataxin and PNKP like factor

NCBI Official Symbol

APLF

NCBI Official Synonym Symbols

APFL; PALF; Xip1; C2orf13

UniProt Protein Name

Aprataxin and PNK-like factor

UniProt Synonym Protein Names

Apurinic-apyrimidinic endonuclease APLF; PNK and APTX-like FHA domain-containing protein; XRCC1-interacting protein 1

Protein Family

Aprataxin and PNK-like factor

UniProt Gene Name

APLF

UniProt Synonym Gene Names

C2orf13; PALF; XIP1

UniProt Entry Name

APLF_HUMAN

NCBI Protein Information

aprataxin and PNK-like factor; XRCC1-interacting protein 1; PNK and APTX-like FHA protein; aprataxin- and PNK-like factor; apurinic-apyrimidinic endonuclease APLF; PNK and APTX-like FHA domain-containing protein

NCBI Summary for APLF

C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]

UniProt Comments for APLF

APLF: Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5. Belongs to the APLF family.

Protein type: EC 4.2.99.18; DNA repair, damage

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; metal ion binding; nucleotide binding; 3'-5' exonuclease activity; endodeoxyribonuclease activity

Biological Process: regulation of isotype switching; single strand break repair; double-strand break repair; positive regulation of DNA ligation; response to DNA damage stimulus; DNA catabolic process, endonucleolytic

Research Articles on APLF

1. APLF promotes the assembly and activity of multi-protein Ku-DNA complexes containing all of the Non-homologous end joining (NHEJ) factors required for DNA ligation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APLF blocking peptide

Reference Product	PubMed Publications
XRCC4 blocking peptide	>8 publications with APLF and XRCC4
XRCC1 blocking peptide	>4 publications with APLF and XRCC1
LIG4 blocking peptide	>1 publications with APLF and LIG4

Diseases associated with APLF blocking peptide

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>2 publications with APLF and Fatty Liver
Weight Loss Antibodies	>1 publications with APLF and Weight Loss

Organs/Tissues associated with APLF blocking peptide

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with APLF and Liver