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ARHGEF6 Antibody (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9221960

MBS9221960 is a blocking peptide targeting ARHGEF6. Also known as ARHGEF6 Antibody (C-term) Blocking Peptide. Acts as a RAC1 guanine nucleotide exchange factor (GEF). More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARHGEF6, Blocking Peptide
Full Product Name
ARHGEF6 Antibody (C-term) Blocking Peptide
Product Gene Name
Product Synonym Gene Name
COOL2; KIAA0006; PIXA
Product Synonym Names
Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6; ARHGEF6; COOL2; KIAA0006; PIXA
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
ARHGEF6 peptide (MBS9221960) is used for blocking the activity of ARHGEF6 antibody (MBS9212259)
Molecular Weight
70,791 Da
OMIM
300267
Cellular Location
Cell projection, lamellipodium
Tissue Location
Ubiquitous.

Other Notes

Small volumes of ARHGEF6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Rho guanine nucleotide exchange factor 6
NCBI Official Synonym Full Names
Rac/Cdc42 guanine nucleotide exchange factor 6
NCBI Official Symbol
ARHGEF6
NCBI Official Synonym Symbols
PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX
UniProt Protein Name
Rho guanine nucleotide exchange factor 6
UniProt Synonym Protein Names
Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6
UniProt Gene Name
ARHGEF6
UniProt Synonym Gene Names
COOL2; KIAA0006; PIXA
UniProt Entry Name
ARHG6_HUMAN
NCBI Protein Information
rho guanine nucleotide exchange factor 6

NCBI Summary for ARHGEF6

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]
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UniProt Comments for ARHGEF6

ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: cytosol; intracellular; lamellipodium

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: lamellipodium biogenesis; positive regulation of apoptosis; regulation of small GTPase mediated signal transduction

Disease: Mental Retardation, X-linked 46
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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