ATG7 Antibody Blocking Peptide

Name: ATG7 Antibody Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9223170
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9223170

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATG7, Blocking Peptide

Full Product Name

ATG7 Antibody Blocking peptide

Product Gene Name

ATG7 blocking peptide

Product Synonym Gene Name

APG7L

Product Synonym Names

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein; ATG7; APG7L

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the R509 region of human Autophagy APG7L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

ATG7 peptide (MBS9223170) is used for blocking the activity of ATG7 antibody (MBS9213191)

Molecular Weight

68,618 Da

OMIM

608760

Cellular Location

Cytoplasm. Preautophagosomal structure. Note: Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme

Tissue Location

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.

Other Notes

Small volumes of ATG7 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATG7 purchase

MBS9223170 is a blocking peptide targeting ATG7. Also known as ATG7 Antibody Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for ATG7. It may not necessarily be applicable to this product.

NCBI GI #

62286592

NCBI GeneID

10533

NCBI Accession #

O95352.1

UniProt Primary Accession #

O95352

UniProt Secondary Accession #

Q7L8L0; Q9BWP2; Q9UFH4; B4E170; E9PB95

UniProt Related Accession #

O95352

NCBI Official Full Name

Ubiquitin-like modifier-activating enzyme ATG7

NCBI Official Synonym Full Names

autophagy related 7

NCBI Official Symbol

ATG7

NCBI Official Synonym Symbols

GSA7; APG7L; APG7-LIKE

UniProt Protein Name

Ubiquitin-like modifier-activating enzyme ATG7

UniProt Synonym Protein Names

ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein

Protein Family

Ubiquitin-like modifier-activating enzyme

UniProt Gene Name

ATG7

UniProt Synonym Gene Names

APG7L; APG7-like; hAGP7

UniProt Entry Name

ATG7_HUMAN

NCBI Protein Information

ubiquitin-like modifier-activating enzyme ATG7

NCBI Summary for ATG7

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

UniProt Comments for ATG7

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Research Articles on ATG7

1. We have identified ATG7 as a potential tissue biomarker distinguishing active EoE from normal, EoE remission, and GERD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ATG7 blocking peptide

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Macroautophagy Pathway antibodies	Macroautophagy Pathway Diagram
Regulation Of Autophagy Pathway antibodies	Regulation Of Autophagy Pathway Diagram
Regulation Of Autophagy Pathway antibodies	Regulation Of Autophagy Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with ATG7 blocking peptide

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>76 publications with ATG7 and Nervous System Diseases
Inflammation Antibodies	>71 publications with ATG7 and Inflammation
Necrosis Antibodies	>66 publications with ATG7 and Necrosis
Liver Diseases Antibodies	>58 publications with ATG7 and Liver Diseases
Cardiovascular Diseases Antibodies	>48 publications with ATG7 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>41 publications with ATG7 and Breast Neoplasms
Lung Diseases Antibodies	>37 publications with ATG7 and Lung Diseases
Adenocarcinoma Antibodies	>37 publications with ATG7 and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>27 publications with ATG7 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>25 publications with ATG7 and Liver Neoplasms

Organs/Tissues associated with ATG7 blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>109 publications with ATG7 and Blood
Brain Antibodies	>104 publications with ATG7 and Brain
Liver Antibodies	>98 publications with ATG7 and Liver
Muscle Antibodies	>90 publications with ATG7 and Muscle
Heart Antibodies	>60 publications with ATG7 and Heart
Lung Antibodies	>56 publications with ATG7 and Lung
Bone Antibodies	>36 publications with ATG7 and Bone
Kidney Antibodies	>32 publications with ATG7 and Kidney
Vascular Antibodies	>24 publications with ATG7 and Vascular
Intestine Antibodies	>24 publications with ATG7 and Intestine