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BLM Antibody (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9225395

Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair:… More details

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Product Overview

Online Datasheet in PDF
Product Name
BLM, Blocking Peptide
Full Product Name
BLM Antibody (C-term) Blocking Peptide
Product Gene Name
BLM blocking peptide
Product Synonym Gene Name
RECQ2; RECQL3
Product Synonym Names
Bloom syndrome protein; DNA helicase; RecQ-like type 2; RecQ2; RecQ protein-like 3; BLM; RECQ2; RECQL3
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
BLM peptide (MBS9225395) is used for blocking the activity of BLM antibody (MBS9214428)
Molecular Weight
159,000 Da
OMIM
210900
Cellular Location
Nucleus. Note: Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner

Other Notes

Small volumes of BLM blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLM purchase

MBS9225395 is a blocking peptide targeting BLM. Also known as BLM Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for BLM. It may not necessarily be applicable to this product.

NCBI GI #
1705486
NCBI GeneID
641
NCBI Accession #
P54132.1
UniProt Primary Accession #
P54132
UniProt Secondary Accession #
Q52M96
UniProt Related Accession #
P54132
NCBI Official Full Name
Bloom syndrome protein
NCBI Official Synonym Full Names
Bloom syndrome RecQ like helicase
NCBI Official Symbol
BLM
NCBI Official Synonym Symbols
BS; RECQ2; RECQL2; RECQL3
UniProt Protein Name
Bloom syndrome protein
UniProt Synonym Protein Names
DNA helicase, RecQ-like type 2; RecQ2; RecQ protein-like 3
Protein Family
Bloom syndrome protein
UniProt Gene Name
BLM
UniProt Synonym Gene Names
RECQ2; RECQL3; RecQ2
UniProt Entry Name
BLM_HUMAN
NCBI Protein Information
Bloom syndrome protein

NCBI Summary for BLM

The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq, Jul 2008]
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UniProt Comments for BLM

BLM: a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2.

Protein type: DNA repair, damage; Helicase; DNA replication; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: chromosome, telomeric region; cytoplasm; lateral element; nuclear chromosome; nuclear matrix; nucleolus; nucleoplasm; nucleus; PML body

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; ATPase activity; bubble DNA binding; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; p53 binding; protein binding; single-stranded DNA binding

Biological Process: DNA double-strand break processing; DNA replication; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of cell division; negative regulation of DNA recombination; positive regulation of transcription, DNA-dependent; protein oligomerization; protein sumoylation; regulation of cyclin-dependent protein kinase activity; replication fork processing; response to DNA damage stimulus; response to X-ray; strand displacement

Disease: Bloom Syndrome
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Research Articles on BLM

1. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating BLM-TOP3A/RMI interactions identified.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BLM blocking peptide

 Reference Product  PubMed Publications
 RAD51 blocking peptide  >101 publications with BLM and RAD51
 ATM blocking peptide  >71 publications with BLM and ATM
 RMI1 blocking peptide  >52 publications with BLM and RMI1
 MLH1 blocking peptide  >19 publications with BLM and MLH1
 TP53 blocking peptide  >17 publications with BLM and TP53
 FANCM blocking peptide  >16 publications with BLM and FANCM
 RPA1 blocking peptide  >13 publications with BLM and RPA1
 TOP3A blocking peptide  >3 publications with BLM and TOP3A
 FANCA blocking peptide  >2 publications with BLM and FANCA

Pathways associated with BLM blocking peptide

 Products by Pathway  Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Bloom's Syndrome Complex Pathway antibodies  Bloom's Syndrome Complex Pathway Diagram
 Bloom's Syndrome Complex Pathway antibodies  Bloom's Syndrome Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram

Diseases associated with BLM blocking peptide

 Disease Name  Pubmed Publications
 Bloom Syndrome Antibodies  >527 publications with BLM and Bloom Syndrome
 Fibrosis Antibodies  >483 publications with BLM and Fibrosis
 Disease Models, Animal Antibodies  >244 publications with BLM and Disease Models, Animal
 Inflammation Antibodies  >158 publications with BLM and Inflammation
 Neoplasms, Experimental Antibodies  >143 publications with BLM and Neoplasms, Experimental
 Chromosome Aberrations Antibodies  >140 publications with BLM and Chromosome Aberrations
 Necrosis Antibodies  >95 publications with BLM and Necrosis
 Anemia Antibodies  >70 publications with BLM and Anemia
 Neoplasm Metastasis Antibodies  >68 publications with BLM and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >62 publications with BLM and Lung Neoplasms

Organs/Tissues associated with BLM blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >555 publications with BLM and Lung
 Blood Antibodies  >396 publications with BLM and Blood
 Kidney Antibodies  >174 publications with BLM and Kidney
 Muscle Antibodies  >122 publications with BLM and Muscle
 Liver Antibodies  >112 publications with BLM and Liver
 Skin Antibodies  >101 publications with BLM and Skin
 Intestine Antibodies  >95 publications with BLM and Intestine
 Lymph Node Antibodies  >62 publications with BLM and Lymph Node
 Brain Antibodies  >62 publications with BLM and Brain
 Connective Tissue Antibodies  >50 publications with BLM and Connective Tissue
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