BRDT Antibody (N-Term) Blocking Peptide

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

BRDT: an atypical protein kinase of the BRD family. Possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. A testis-specific protein that is also expressed at a high level in non-small cell lung cancer

Protein type: Cancer Testis Antigen (CTA); Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Kinase, protein; ATYPICAL group; BRD family

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: nucleus

Molecular Function: histone binding; transcription coactivator activity

Biological Process: chromatin remodeling; male meiosis; male meiosis I; positive regulation of transcription, meiotic; regulation of RNA splicing; spermatogenesis