BTRC Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: BTRC Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9625906
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9625906

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BTRC, Blocking Peptide

Full Product Name

BTRC Blocking Peptide

Product Gene Name

BTRC blocking peptide

Product Synonym Names

Beta transducin repeat containing E3 ubiquitin protein ligase; beta TrCP1; beta-transducin repeat containing; BETA-TRCP; betaTrCP; btrC; bTrCP; bTrCP1; E3RSIkappaB; F box and WD repeat protein 1B; F box and WD repeats protein beta TrCP; F-box and WD repeats protein beta-TrCP; F-box/WD repeat protein 1A; F-box/WD repeat-containing protein 1A; FBW1A; FBW1A_HUMAN; FBXW1; FBXW1A; FWD1; HOS; mKIAA4123; pIkappaBalpha-E3 receptor subunit; Slimb

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

BTRC peptide (MBS9625906) is used for blocking the activity of BTRC antibody (MBS9607190)

Molecular Weight

68,867 Da

OMIM

603482

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for BTRC blocking peptide

Blocking/Control

Other Notes

Small volumes of BTRC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BTRC purchase

MBS9625906 is a blocking peptide targeting BTRC.

Additional Details

NCBI/Uniprot data below describe general gene information for BTRC. It may not necessarily be applicable to this product.

NCBI GI #

4502477

NCBI GeneID

8945

NCBI Accession #

NP_003930.1

UniProt Primary Accession #

Q9Y297

UniProt Secondary Accession #

Q5W141; Q5W142; Q9Y213; B5MD49

UniProt Related Accession #

Q9Y297

GenBank Nucleotide #

NM_003939.4

NCBI Official Full Name

F-box/WD repeat-containing protein 1A isoform 2

NCBI Official Synonym Full Names

beta-transducin repeat containing E3 ubiquitin protein ligase

NCBI Official Symbol

BTRC

NCBI Official Synonym Symbols

FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP

UniProt Protein Name

F-box/WD repeat-containing protein 1A

UniProt Synonym Protein Names

E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit

Protein Family

F-box/WD repeat-containing protein

UniProt Gene Name

BTRC

UniProt Synonym Gene Names

BTRCP; FBW1A; FBXW1A

UniProt Entry Name

FBW1A_HUMAN

NCBI Protein Information

F-box/WD repeat-containing protein 1A; beta-TrCP1; E3RSIkappaB; F-box and WD-repeat protein 1B; epididymis tissue protein Li 2a; pIkappaBalpha-E3 receptor subunit; F-box and WD repeats protein beta-TrCP

UniProt Comments for BTRC

BTRC: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Regulates the stability of CTNNB1 and participates in Wnt signaling. Interacts directly with SKP1 in the SCF complex. Interacts specifically with phosphorylated CTNNB1 and NFKBIA, ubiquitination substrates. Two alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: nucleoplasm; SCF ubiquitin ligase complex; cytosol

Molecular Function: protein dimerization activity; protein phosphorylated amino acid binding; protein binding; ubiquitin-protein ligase activity; beta-catenin binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; circadian rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; viral reproduction; regulation of cell cycle; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; protein ubiquitination; positive regulation of circadian rhythm; protein amino acid dephosphorylation; signal transduction; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle; regulation of I-kappaB kinase/NF-kappaB cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein destabilization; negative regulation of transcription factor activity; mammary gland epithelial cell proliferation; regulation of circadian rhythm; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of smoothened signaling pathway; mitotic cell cycle; negative regulation of transcription, DNA-dependent

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BTRC blocking peptide

Reference Product	PubMed Publications
CTNNB1 blocking peptide	>37 publications with BTRC and CTNNB1
SKP1 blocking peptide	>23 publications with BTRC and SKP1
FBXW11 blocking peptide	>11 publications with BTRC and FBXW11
APC blocking peptide	>9 publications with BTRC and APC
CUL1 blocking peptide	>9 publications with BTRC and CUL1
CDC25A blocking peptide	>2 publications with BTRC and CDC25A
NFKB2 blocking peptide	>1 publications with BTRC and NFKB2

Pathways associated with BTRC blocking peptide

Products by Pathway	Pathway Diagram
AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies	AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies	APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies	APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies	AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies	AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Alternative NF-kappaB Pathway antibodies	Alternative NF-kappaB Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram

Diseases associated with BTRC blocking peptide

Disease Name	Pubmed Publications
Necrosis Antibodies	>10 publications with BTRC and Necrosis
Nervous System Diseases Antibodies	>8 publications with BTRC and Nervous System Diseases
Brain Diseases Antibodies	>7 publications with BTRC and Brain Diseases
Central Nervous System Diseases Antibodies	>7 publications with BTRC and Central Nervous System Diseases
Congenital Abnormalities Antibodies	>5 publications with BTRC and Congenital Abnormalities
Inflammation Antibodies	>4 publications with BTRC and Inflammation
Cardiovascular Diseases Antibodies	>3 publications with BTRC and Cardiovascular Diseases
Lung Neoplasms Antibodies	>3 publications with BTRC and Lung Neoplasms
Prostatic Diseases Antibodies	>2 publications with BTRC and Prostatic Diseases
Death Antibodies	>2 publications with BTRC and Death

Organs/Tissues associated with BTRC blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with BTRC and Brain
Vascular Antibodies	>5 publications with BTRC and Vascular
Skin Antibodies	>4 publications with BTRC and Skin
Lung Antibodies	>4 publications with BTRC and Lung
Muscle Antibodies	>4 publications with BTRC and Muscle
Intestine Antibodies	>2 publications with BTRC and Intestine
Prostate Antibodies	>2 publications with BTRC and Prostate
Heart Antibodies	>2 publications with BTRC and Heart
Embryonic Tissue Antibodies	>2 publications with BTRC and Embryonic Tissue
Connective Tissue Antibodies	>1 publications with BTRC and Connective Tissue