CCL3 Blocking Peptide (C-Term) Blocking Peptide

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]

CCL3: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; intracellular

Molecular Function: calcium-dependent protein kinase C activity; CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; identical protein binding; kinase activity; phospholipase activator activity; protein binding; protein kinase activity

Biological Process: astrocyte cell migration; behavior; calcium ion transport; calcium-mediated signaling; cell activation; cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; eosinophil degranulation; exocytosis; G-protein coupled receptor protein signaling pathway; inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of bone mineralization; negative regulation of osteoclast differentiation; neutrophil chemotaxis; osteoblast differentiation; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of neuron apoptosis; positive regulation of protein kinase B signaling cascade; positive regulation of tumor necrosis factor production; protein kinase B signaling cascade; regulation of cell shape; regulation of sensory perception of pain; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to toxin

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To