CCR1 Blocking Peptide (C-Term) Blocking Peptide

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; phosphoinositide phospholipase C activity; protein binding

Biological Process: calcium ion transport; cell adhesion; cell surface receptor linked signal transduction; cell-cell signaling; cellular calcium ion homeostasis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; exocytosis; G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; negative regulation of bone mineralization; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of osteoclast differentiation; response to wounding