Mouse Cdkn1b Antibody (N-Term) Blocking Peptide

p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Inhibitor; Oncoprotein; Cell cycle regulation; Protein kinase, regulatory subunit

Cellular Component: cytoplasm; cytosol; nucleus; protein complex

Molecular Function: caspase activator activity; chaperone binding; cyclin-dependent protein kinase inhibitor activity; Hsp70 protein binding; protein binding; protein complex binding; protein phosphatase binding

Biological Process: autophagic cell death; caspase activation; cell cycle arrest; cell death; G1/S transition of mitotic cell cycle; inner ear development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of epithelial cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of microtubule polymerization; potassium ion transport; sensory perception of sound