CHRNA4 Blocking Peptide (C-Term) Blocking Peptide

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: cell soma; dendrite; external side of plasma membrane; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity

Biological Process: B cell activation; behavioral response to nicotine; calcium ion transport; cognition; DNA repair; membrane depolarization; neurological system process; neuromuscular synaptic transmission; regulation of action potential; regulation of dopamine secretion; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission, cholinergic

Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To