CHST2 Antibody (Center) Blocking Peptide

CHST2: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 2.8.2.-; Membrane protein, integral; Transferase; Glycan Metabolism - keratan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: Golgi membrane; integral to membrane; trans-Golgi network

Molecular Function: N-acetylglucosamine 6-O-sulfotransferase activity; sulfotransferase activity

Biological Process: keratan sulfate biosynthetic process; multicellular organismal development; N-acetylglucosamine metabolic process; sulfur metabolic process